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Molecules 2015, 20(11), 20063-20078; doi:10.3390/molecules201119676

Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan
2
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan
3
Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Emília de Sousa
Received: 17 September 2015 / Revised: 20 October 2015 / Accepted: 21 October 2015 / Published: 6 November 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1352 KB, uploaded 6 November 2015]   |  

Abstract

Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea compounds as antihyperglycaemic agents in streptozocine-induced diabetic mice. The rational for the introduction of the glucosamine moiety is to enhance selective drug uptake by pancreatic β-cells in order to decrease the cardiotoxic side effect commonly associated with sulfonylurea agents. 2-Deoxy-2-(4-chlorophenylsulfonylurea)-d-glucopyranose was found to be the most potent antihyperglycaemic agents among the synthesized compounds in diabetic mice. This investigation indicates the importance of this novel class as potential antihyperglycaemic agents. View Full-Text
Keywords: sulphonylurea; antihyperglycemic agents; glucosamine; streptozocine sulphonylurea; antihyperglycemic agents; glucosamine; streptozocine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Suaifan, G.A.R.Y.; Shehadeh, M.B.; Darwish, R.M.; Al-Ijel, H.; Abbate, V. Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents. Molecules 2015, 20, 20063-20078.

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