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Molecules 2015, 20(11), 19789-19804; doi:10.3390/molecules201119657

Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors

1
Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea
2
Division of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, Korea
3
Department of Food Science & Technology, and Functional Food Research Center, Chonnam National University, Gwangju 500-757, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 22 June 2015 / Revised: 26 October 2015 / Accepted: 27 October 2015 / Published: 3 November 2015
(This article belongs to the Collection Bioactive Compounds)
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Abstract

We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4′-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data. View Full-Text
Keywords: Artemisia scoparia; halophyte; blood pressure; ACE inhibitor; phenolics Artemisia scoparia; halophyte; blood pressure; ACE inhibitor; phenolics
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Cho, J.-Y.; Park, K.-H.; Hwang, D.Y.; Chanmuang, S.; Jaiswal, L.; Park, Y.-K.; Park, S.-Y.; Kim, S.-Y.; Kim, H.-R.; Moon, J.-H.; Ham, K.-S. Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors. Molecules 2015, 20, 19789-19804.

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