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Molecules 2015, 20(10), 19620-19646; doi:10.3390/molecules201019620

Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs

1
and
1,2,3,*
1
Center for Biotechnology Research in UBITA (CBRU), Institute for Ubiquitous Information Technology and Applications (UBITA), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
2
Microbial Carbohydrate Resource Bank (MBRC), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
3
Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Holger Grohganz
Received: 15 September 2015 / Revised: 16 October 2015 / Accepted: 22 October 2015 / Published: 27 October 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1158 KB, uploaded 27 October 2015]   |  

Abstract

In this review, a comprehensive overview of advances in the supramolecular complexes of carbohydrates and poorly soluble drugs is presented. Through the complexation process, poorly soluble drugs could be efficiently delivered to their desired destinations. Carbohydrates, the most abundant biomolecules, have diverse physicochemical properties owing to their inherent three-dimensional structures, hydrogen bonding, and molecular recognition abilities. In this regard, oligosaccharides and their derivatives have been utilized for the bioavailability enhancement of hydrophobic drugs via increasing the solubility or stability. By extension, polysaccharides and their derivatives can form self-assembled architectures with poorly soluble drugs and have shown increased bioavailability in terms of the sustained or controlled drug release. These supramolecular systems using carbohydrate will be developed consistently in the field of pharmaceutical and medical application. View Full-Text
Keywords: poorly soluble drugs; carbohydrates; supramolecular complexation; bioavailability enhancement poorly soluble drugs; carbohydrates; supramolecular complexation; bioavailability enhancement
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cho, E.; Jung, S. Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs. Molecules 2015, 20, 19620-19646.

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