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Article

A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles

by
Phuong Hoang Tran
1,
Hai Ngoc Tran
1,
Poul Erik Hansen
2,*,
Mai Hoang Ngoc Do
1 and
Thach Ngoc Le
1
1
Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City 70000, Vietnam
2
Department of Science, Systems and Models, Roskilde University, POB 260, Roskilde DK-4000, Denmark
*
Author to whom correspondence should be addressed.
Molecules 2015, 20(10), 19605-19619; https://doi.org/10.3390/molecules201019605
Submission received: 5 October 2015 / Revised: 22 October 2015 / Accepted: 22 October 2015 / Published: 27 October 2015
(This article belongs to the Special Issue Ionic Liquids in Organic Synthesis)
Browse Figures
Versions Notes

Abstract

:
A fast and green method is developed for regioselective acylation of indoles in the 3-position without the need for protection of the NH position. The method is based on Friedel-Crafts acylation using acid anhydrides. The method has been optimized, and Y(OTf)3 in catalytic amounts is found to be the best catalyst together with the commercially available ionic liquid [BMI]BF4 (1-butyl-3-methylimidazolium tetrafluoro-borate) as solvent. The reaction is completed in a very short time using monomode microwave irradiation. The catalyst can be reused up to four times without significant loss of activity. A range of substituted indoles are investigated as substrates, and thirteen new compounds have been synthesized.

Graphical Abstract

1. Introduction

3-Acylindoles are useful intermediates in the synthesis of various pharmaceuticals [1,2,3,4]. Regioselectivity in the 3-acylation of indoles has been an interesting and challenging subject in organic synthesis. A wide range of 3-acylindoles was synthesized by several methods such as Friedel-Crafts acylation [5,6,7,8,9,10,11,12], Vilsmeier-Haack type reaction [4,13], α-aminocarbonyl compounds with palladium [14], carbamoyl electrophiles [2], α-oxocarboxylic acids [15,16,17], and nitrilium salt with palladium [18]. Among those, Friedel-Crafts acylation of free (NH) indoles is definitely the simplest way [19], however, low yields were observed due to competing substitution at the 1-position. Therefore, N-acylated and 1,3-diacylated products were obtained, or indole polymerization may occur in the Friedel-Crafts acylation. To reduce these side products, NH-protection was necessary [8,20]. The protection-deprotection steps are not green and convenient methods [21]. Besides, traditional Lewis acid-catalyzed Friedel-Crafts acylation must be carried out under strictly anhydrous conditions and requires a greater than stoichiometric amount of Lewis acid [22]. Aluminum trichloride, a well-known Lewis acid commonly used in Friedel-Crafts acylations requires a complicated work-up process and causes environmental problems [22]. The development of alternative Lewis acid-catalyzed 3-acylations of indoles has been studied intensively [19]. Among these alternative Lewis acid catalysts, metal triflates were a good option in various organic reactions [19]. In comparison to traditional Lewis acids, metal triflate-catalysed Friedel-Crafts acylation does not require strictly anhydrous conditions due to their water-tolerant characteristics [23]. Besides, only 1–5 mole % of metal triflate is sufficient for complete conversion [23]. Furthermore, this can easily be recovered after workup.
Although metal triflates have been applied extensively in Friedel-Crafts acylation of aromatic compounds [24,25,26,27,28], there has been only one report on the use of indium triflate for the acylation of indoles [29]. However, in that case, excess reagent and NH-protection were required to obtain 3-acylated indoles in good yields. Recently, metal triflates dissolved in ionic liquids were found to be a good catalytic system in Friedel-Crafts acylations [30]. The Friedel-Crafts acylation using metal triflate in ionic liquids has been shown to increase the yield with high regioselectivity and to simplify the recovery of the catalyst [31,32,33,34,35,36,37].
Microwave-mediated organic synthesis provides a useful method due to specific interactions and energy efficiency. Microwave irradiation has allowed the design of efficient processes with significant improvements of yield and selectivity in a short reaction time and simplification of product purification [38].
We report here the development of a new method for the Friedel-Crafts 3-acylation of indoles with various acid anhydrides using metal triflates in ionic liquids under microwave activation. In this paper, we are especially interested in rare-earth metal triflates due to their high catalytic activity and imidazolium ionic liquids because they are commercially available.

2. Results and Discussion

The first step was to find the best catalyst from among fourteen metal triflates, including ten rare-earth metal triflates and four well-known triflates such as bismuth triflate, indium triflate, copper triflate and yttrium triflate. The acylation of indole with propionic anhydride was chosen as the model reaction. Indole was treated with 1 mol % of metal triflate in the presence of 1 equiv. of propionic anhydride under microwave irradiation at 120 °C for 5 min. The results are presented in Table 1. Among these triflates, yttrium triflate showed the best catalytic activity for Friedel-Crafts 3-propionylation of indole. Rare-earth metal triflates were also efficient (73%–81%), while bismuth and praseodynium triflates are demonstrated to be less reactive than the others. Interestingly, direct Friedel-Crafts 3-propionylation of indole gave the desired 3-propionylindole without formation of dipropionylated product and polymers, and less than 5% of N-propionylated product was found in all cases (with the exception of bismuth triflate, with 9% N-propionylindole). Yttrium triflate showed the highest yield and exhibited stronger catalytic activity than the other metal triflates. This metal triflate has been studied extensively in organic synthesis in general [39,40,41,42,43,44,45,46,47,48].
Table
Table 1. Effect of metal triflates on Friedel-Crafts propionylation of indoles under microwave irradiation. Molecules 20 19605 i001
Table 1. Effect of metal triflates on Friedel-Crafts propionylation of indoles under microwave irradiation. Molecules 20 19605 i001
0Metal TriflateIsolated Yield (%)Selective Position (1-/2-/3-)
1Cu(OTf)2745/0/95
2Y(OTf)3843/0/97
3In(OTf)3804/0/96
4Bi(OTf)3709/0/91
5La(OTf)3814/0/96
6Ce(OTf)3794/0/96
7Pr(OTf)3704/0/96
8Nd(OTf)3745/0/95
9Eu(OTf)3734/0/96
10Gd(OTf)3765/0/95
11Tb(OTf)3764/0/96
12Dy(OTf)3784/0/96
13Ho(OTf)3754/0/96
14Tm(OTf)3804/0/96
Next, we tested the effect of solvents on Friedel-Crafts propionylation of indole. The aim of this test was to find the solvent leading to the highest yield with maximum formation of only 3-propionylindole. Eighteen solvents, including traditional organic solvents and commercially available ionic liquids, were investigated. The results are listed in Table 2. The ionic liquid [BMI]BF4 was found to be the most effective for Friedel-Crafts propionylation of indole in excellent yield with high regioselectivity, and in this case N-propionylation was completely absent. The result indicates that the presence of [BMI]BF4 enhances the catalytic activity of yttrium triflate. Friedel-Crafts acylation using metal triflates in ionic liquids has recently attracted attention [31,32,33,34,35,36,37,49]. However, this is the first time that tis catalytic system was applied in the Friedel-Crafts acylation of indoles.
Table
Table 2. Effect of solvents under microwave irradiation (80 °C, 5 min) a. Molecules 20 19605 i002
Table 2. Effect of solvents under microwave irradiation (80 °C, 5 min) a. Molecules 20 19605 i002
EntrySolventYield b (%)Selective Position (1-/2-/3-) c
1n-hexane205/0/95
2cyclopentyl methyl ether509/0/91
3tert-butyl methyl ether270/0/100
4dioxane633/0/97
5tetrahydrofuran504/0/96
6ethyl acetate633/0/97
7chloroform3410/0/90
8dichloromethane220/0/100
9acetone4437/0/63
10acetonitrile682/0/100
11methanol0-
12dimethyl carbonate573/0/97
13[BMI]BF4920/0/100
14[BMI]Cl665/0/95
15[BMI]PF6703/0/97
16[BMI]SCN4322/0/78
17[BPy]OTf686/0/94
18[EMI]Cl744/0/96
a Indole (1 mmol), propionic acid anhydride (1 mmol), yttrium triflate (0.01 mmol). b Isolated yield. c Isomers were determined by GC.
With optimized conditions in hand, we next investigated the substrate and reagent scope for the Friedel-Crafts 3-acylation of indoles with acid anhydrides using yttrium triflate in [BMI]BF4, and the results are presented in Table 3. Indole afforded 3-acylindole in excellent yields with high regioselectivity for the 3-position when using aliphatic acid anhydrides as acylating reagents (Table 3, entries 1–5). Benzoylation of indole gave the desired product in only 78% yield due to competing N-benzoylation (Table 3, entry 6). For indoles with electron-rich substituents on the phenyl ring, indoles such as 5-methylindole and 5-methoxyindole, gave 3-acylindoles in yields of 78%–83% without polymerization or side products. The slightly lower yields of 3-acylated products are due to increased substitution at the 1- and 2-position (Table 3, entries 7–18). However, acylation of 4- or 5-haloindoles with aliphatic acid anhydrides produced 3-acylindoles in good yields (Table 3, entries 19–34). In addition, N-acylated byproducts were slightly decreased in comparison with electron-rich indoles, but 2-acylindoles were obtained in small amounts (Table 3, entries 19–29). A variety of aliphatic acid anhydrides have been tested. Good yields were obtained for both straight-chain and branched-chain acid anhydrides. Effects due to steric hindrance do not play a role as pivalic acid anhydride is also reactive in general (Table 3). The use of microwave irradiation is probably very important in the case of pivalic acid anhydride as pivaloyl chloride under Friedel-Crafts conditions are known to lead to decarbonylation [50]. The reaction has also been tested using conventional heating for 5 min. at 80 °C with catalyst and in IL. With indole and propionic acid anhydride the yield was 16% (6/0/94) and with butyric acid anhydride 28% (5/0/95). The regioselectivity was worse and much longer times are needed. Looking at regioselectivity in general, it is seen from Table 1 that the catalyst has little influence. From Table 2, most solvents give good regioselectivity. The exceptions are acetone and [BMI]SCN. It is hard to find a common factor for those conditions. It can be added that using propionic anhydride with indole gave a ratio of 7/93 but only in 20% yield in the absence of catalyst. From Table 3, it is seen that pivalic acid anhydride and 2-methylpropionic acid anhydride give rise to more 2-substitution than straight chain acid anhydrides and so does benzoic acid anhydride. A comparison of entries 23 and 34 shows that the reason is not purely steric. More important seems to be the nature of the substitutent in the 5-position. As the three mentioned acylium ions are more stable than those of straight chain acylium ions, it appears that a higher yield of the 2-isomer is caused by a combination of a small steric effect, electronic influence of the 5-position and the stability of the acylium ion.
Table
Table 3. Friedel-Crafts acylation of indoles using Y(OTf)3/[BMI]BF4 under monomode microwave irradiation a. Molecules 20 19605 i003
Table 3. Friedel-Crafts acylation of indoles using Y(OTf)3/[BMI]BF4 under monomode microwave irradiation a. Molecules 20 19605 i003
EntrySubstrateR′Selective Position in Parenthesis b(1-/2-/3-)Isolated Yield (%) of 3-Substituted Derivative c
1 Molecules 20 19605 i004CH30/0/10088 d
2C2H50/0/10092
3C3H73/0/9788 e
4i-C3H72/2/9691
5t-C4H91/4/9589
6C6H55/3/9278 f
7 Molecules 20 19605 i005CH36/0/9479 g
8C2H56/1/9380
9C3H77/2/9179
10i-C3H71/8/9180
11t-C4H91/6/9383
12C6H53/4/9383
13 Molecules 20 19605 i006CH38/0/92 79 g
14C2H56/2/9278
15C3H76/2/9280
16i-C3H72/7/9178
17t-C4H91/4/9579
18C6H57/4/8978
19 Molecules 20 19605 i007CH34/2/9483 h
20C2H54/1/9585 g
21C3H75/2/9378
22i-C3H72/5/9380
23t-C4H91/4/9580 g
24C6H5not determined i75
25 Molecules 20 19605 i008CH33/1/9679 h
26C2H52/2/9682
27C3H73/2/9580
27i-C3H72/7/9179
29t-C4H96/15/7965 g
30C6H51/9/9077
31 Molecules 20 19605 i009C2H53/3/9480
32t-C4H93/39/5845
33 Molecules 20 19605 i010C2H510/0/9072
34t-C4H94/4/9282
a Reaction conditions: indoles (1 mmol), acid anhydrides (1 mmol) and Y(OTf)3 (0.01 mmol), [BMI]BF4 (1 mmol) at 80 °C for 5 min unless otherwise noted. Other conditions were tested to obtain the best yield. b Selectivity was determined by GC. c Isolated yield of pure isomer. d 110 °C, 10 min. e 100 °C, 5 min. f 100 °C, 1 min. g 80 °C, 10 min. h 100 °C, 10 min, i the compounds is not suitable for GC analysis.
The reusability of Y(OTf)3/[BMI]BF4 was also studied. After the first use, the recovered catalytic system was tested in four consecutive runs without significant loss of catalytic activity in propionylation of indole and 5-bromoindole (Scheme 1). The recovery of yttrium triflate in [BMI]BF4 is simple. After workup, the ionic liquid containing metal triflate is dried under vacuum before the next use.
Molecules 20 19605 g001 550
Scheme 1. Recycling of Y(OTf)3/[BMI]BF4 in four consecutive runs under microwave irradiation.
Scheme 1. Recycling of Y(OTf)3/[BMI]BF4 in four consecutive runs under microwave irradiation.
Molecules 20 19605 g001

3. Experimental Section

3.1. Chemicals and Supplies

Indoles, acid anhydrides and metal triflates were purchased from Sigma-Aldrich (St. Louis, MO, USA) and immediately used without further purification. Solvents were obtained from Labscan (Bangkok, Thailand) and Chemsol (Hochiminhcity, Vietnam) and also directly used without purification. Silica gel was from Merck (Darmstadt, Germany).

3.2. Instruments

Microwave irradiation was performed in a CEM Discover BenchMate apparatus (Matthews, NC, USA) which allows microwave synthesis with safe pressure regulation using a 10 mL pressurized glass tube with Teflon-coated septum and vertically-focused IR temperature sensor controlling reaction temperature. Flash column chromatography was performed on silica gel (Merck). GC-MS analyses were performed on an Agilent GC System 7890 (Santa Clara, CA, USA) equipped with an Agilent 5973N mass selective detector and a DB-5MS capillary column (30 m × 250 µm × 0.25 µm). The 1H- and 13C-NMR spectra were recorded on an Advance 500 (Bruker, Rheinstetten, Germany) and Mercury 300 (Varian, Palo Alto, CA, USA) instrument using DMSO-d6 or CDCl3 as solvent and solvent peaks or TMS as internal standards. HRMS (ESI) data were recorded on Bruker micrOTOF-QII MS (Bruker, Bremen, Germany) at 80 eV.

3.3. Acylation Procedure

A 10 mL glass vessel suited for the monomode microwave oven was charged with 1 mmol substrate, 1 mmol acid anhydride, 0.01 mmol metal triflate, and 1 mmol ionic liquid. Next, the vessel was sealed with a Teflon cap and irradiated in a monomode microwave oven at many different reaction conditions (temperature and time) to find the optimal condition. Upon completion, the vessel was cooled down to room temperature and the mixture was extracted with Et2O (5 × 10 mL). The ether layer was decanted and washed with water (2 × 10 mL), saturated aqueous NaHCO3 (2 × 20 mL), and brine (2 × 10 mL). The organic layer was dried over MgSO4, filtered, and the solvent was removed by a rotary evaporator. The isolated yield was determined after purification by flash chromatography (silica gel, n-hexane/ethyl acetate, gradient 10:0 to 8:2).

3.4. Recovery and Reuse of the Catalytic System Y(OTf)3/[BMI]BF4

This procedure was also carried out in the monomode microwave oven using indole or 5-bromoindole. In order to recover the catalytic Y(OTf)3/[BMI]BF4 system after completion of the reaction, diethyl ether was applied to wash the reaction mixture as many times as necessary to completely remove both substrates and products. Then, the mixture Y(OTf)3/[BMI]BF4 was dried in vacuum at 80 °C for 30 min. Due to its high solubility in the ionic liquid [BMI]BF4, Y(OTf)3 could easily be recovered in a quantitative yield. This recycled system was used for four consecutive runs and it can be noticed that the isolated yield of product only decreased slightly after each run. The process for recycling Y(OTf)3 in [BMI]BF4 is simple and efficient so it easily can be applied on a large scale.

3.5. Compounds

New compounds have been synthesized as follows:
3-Propionyl-5-Methylindole
Molecules 20 19605 i011
Pale yellow solid, mp. 208–209 °C. 1H-NMR (300 MHz, DMSO-d6): δ 11.75 (br s, 1H), 8.23 (s, 1H), 8.04–7.93 (m, 1H), 7.33 (d, J = 8.3 Hz, 1H), 7.02 (dd, J = 8.3, 1.5 Hz, 1H), 2.84 (q, J = 7.4 Hz, 2H), 2.39 (s, 3H), 1.10 (t, J = 7.4 Hz, 3H). 13C-NMR (75 MHz, DMSO-d6): δ 195.7, 134.9, 133.4, 130.3, 125.7, 124.1, 121.0, 115.6, 111.6, 31.8, 21.3, 9.2. GC-MS (EI, 70 eV): m/z (%) = 187 (25, [M+]). HR-ESI-MS m/z calcd. for ([M + Na]+) 210.0889, found 210.0917.
3-Butyryl-5-methylindole
Molecules 20 19605 i012
Pale yellow solid, mp. 190–191 °C. 1H-NMR (300 MHz, DMSO-d6) δ 11.75 (br s, 1H), 8.26–8.22 (m, 1H), 8.00 (d, J = 2.0 Hz, 1H), 7.30 (s, 1H), 7.01 (s, 1H), 2.77 (t, J = 7.3 Hz, 2H), 2.37 (s, 3H), 1.64 (sext, J = 7.4 Hz, 2H), 0.91 (t, J = 7.4 Hz, 3H). 13C-NMR (75 MHz, DMSO-d6) δ 195.2, 134.9, 133.6, 130.2, 125.6, 124.0, 121.1, 116.1, 111.6, 35.7, 18.3, 13.8. GC-MS (EI, 70 eV): m/z (%) = 201 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 224.1046, found 224.1053.
3-Isobutyryl-5-methylindole
Molecules 20 19605 i013
Pale yellow solid, mp. 210–211 °C. 1H-NMR (300 MHz, DMSO-d6): δ 11.76 (br s, 1H), 8.26 (d, J = 3.1 Hz, 1H), 8.00 (s, 1H), 7.31 (d, J = 8.3 Hz, 1H), 7.00 (dd, J = 8.3, 1.6 Hz, 1H), 3.41 (hept, J = 6.8 Hz, 1H), 2.37 (s, 3H), 1.09 (d, J = 6.8 Hz, 6H). 13C-NMR (75 MHz, DMSO-d6): δ 199.3, 135.0, 133.4, 130.3, 126.0, 124.1, 121.2, 114.6, 111.6, 35.7, 21.3, 19.8. GC-MS (EI, 70 eV): m/z (%) = 201 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 224.1046, found 224.1063.
3-Propionyl-5-methoxyindole
Molecules 20 19605 i014
White solid, mp. 182–183 °C. 1H-NMR (300 MHz, DMSO-d6): δ 11.74 (br s, 1H), 8.21 (s, 1H), 7.69 (d, J = 2.5 Hz, 1H), 7.33 (d, J = 8.8 Hz, 1H), 6.81 (dd, J = 8.8, 2.6 Hz, 1H), 3.75 (s, 3H), 2.82 (q, J = 7.4 Hz, 2H), 1.09 (t, J = 7.4 Hz, 3H). 13C-NMR (75 MHz, DMSO-d6): δ 195.7, 155.3, 133.6, 131.4, 126.1, 115.8, 112.7, 112. 103.0, 55.2, 31.7, 9.1. GC–MS (EI, 70 eV): m/z (%) = 203 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 226.0839, found 226.0856.
3-Butyryl-5-methoxyindole
Molecules 20 19605 i015
White solid, mp. 166–167 °C. 1H-NMR (300 MHz, DMSO-d6): δ 11.77 (s, 1H), 8.24 (s, 1H), 7.72 (d, J = 2.5 Hz, 1H), 7.34 (d, J = 8.8 Hz, 1H), 6.83 (dd, J = 8.8, 2.6 Hz, 1H), 3.77 (s, 3H), 2.79 (t, J = 7.4 Hz, 2H), 1.66 (sext, J = 7.4 Hz, 2H), 0.94 (t, J = 7.4 Hz, 3H). 13C-NMR (75 MHz, DMSO-d6): δ 195.2, 155.3, 133.8, 131.4, 126.1, 116.3, 112.7, 112.6, 103.0, 55.2, 40.5, 18.3, 13.9. GC–MS (EI, 70 eV): m/z (%) = 217 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 240.0995, found 240.1026.
3-Isobutyryl-5-methoxyindole
Molecules 20 19605 i016
White solid, mp. 158–159 °C. 1H-NMR (500 MHz, CDCl3): δ 8.77 (br s, 1H), 7.97 (d, J = 2.5 Hz, 1H), 7.85 (d, J = 3.0 Hz, 1H), 7.29 (d, J = 8.8 Hz, 1H), 6.92 (dd, J = 8.8, 2.5 Hz, 1H), 3.87 (s, 3H), 3.33 (hept, J = 6.8 Hz, 1H), 1.27 (d, J = 6.8 Hz, 7H). 13C-NMR (125 MHz, CDCl3): δ 201.1, 156.4, 131.3, 131.0, 126.7, 116.6, 114.4, 112.1, 103.6, 55.7, 37.1, 19.8. GC-MS (EI, 70 eV): m/z (%) = 217 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 240.0995, found 240.1035.
3-Pivaloyl-5-methoxyindole
Molecules 20 19605 i017
White solid, mp. 153–154 °C. 1H-NMR (300 MHz, DMSO-d6): δ 11.74 (s, 1H), 8.29 (d, J = 1.9 Hz, 1H), 7.84 (d, J = 2.5 Hz, 1H), 7.33 (d, J = 8.8 Hz, 1H), 6.81 (dd, J = 8.8, 2.6 Hz, 1H), 3.77 (s, 3H), 1.33 (s, 9H). 13C-NMR (75 MHz, DMSO-d6): δ 201.5, 155.7, 133.1, 131.0, 128.4, 113.0, 112.8, 112.5, 104.1, 55.6, 43.8, 29.1. GC-MS (EI, 70 eV): m/z (%) = 231 (15, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 254.1152, found 254.1189.
3-Isobutyryl-5-bromoindole
Molecules 20 19605 i018
White solid, mp. 223–224 °C. 1H-NMR (300 MHz, DMSO-d6): δ 12.11 (br s, 1H), 8.42 (s, 1H), 8.35 (dd, J = 2.0, 0.5 Hz, 1H), 7.44 (dd, J = 8.6, 0.5 Hz, 1H), 7.33 (dd, J = 8.6, 2.0 Hz, 1H), 3.44 (hept, J = 6.8 Hz, 1H), 1.12 (d, J = 6.8 Hz, 6H). 13C-NMR (75 MHz, DMSO-d6): δ 199.5, 135.4, 134.7, 127.5, 125.3, 123.6, 114.4, 114.4, 114.1, 35.8, 19.7. GC-MS (EI, 70 eV): m/z (%) = 265 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 287.9994, found 288.0006.
3-Pivaloyl-5-bromoindole
Molecules 20 19605 i019
White solid, mp. 234–235 °C. 1H-NMR (300 MHz, DMSO-d6): δ 12.04 (br s, 1H), 8.42 (dd, J = 2.0, 0.5 Hz, 1H), 8.40 (s, 1H), 7.41 (dd, J = 8.6, 0.5 Hz, 1H), 7.30 (dd, J = 8.6, 2.0 Hz, 1H), 1.31 (s, 9H). 13C-NMR (75 MHz, DMSO-d6): δ 201.1, 134.3, 133.6, 128.9, 125.0, 124.1, 114.2, 113.7, 111.6, 43.3, 28.3. GC-MS (EI, 70 eV): m/z (%) = 279 (15, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 302.0151, found 302.0186.
3-Butyryl-5-chloroindole
Molecules 20 19605 i020
Pale yellow solid, mp. 214–215 °C. 1H-NMR (500 MHz, CDCl3): δ 8.60 (br s, 1H), 8.42 (d, J = 2.0 Hz, 1H), 7.87 (d, J = 2.9 Hz, 1H), 7.33 (d, J = 8.6 Hz, 1H), 7.24 (J = 8.7, 2.1 Hz, 1H), 2.83 (t, J = 7.4 Hz, 2H), 1.81 (sext, J = 7.4 Hz, 2H), 1.03 (t, J = 7.4 Hz, 3H). 13C-NMR (125 MHz, CDCl3): δ 196.1, 134.6, 131.5, 130.2, 126.6, 124.2, 122.2, 118.1, 112.2, 41.8, 18.4, 14.0. GC-MS (EI, 70 eV): m/z (%) = 221 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 244.0499, found 244.0472.
3-Isobutyryl-5-chloroindole
Molecules 20 19605 i021
Pale yellow solid, mp. 198–199 °C. 1H-NMR (500 MHz, CDCl3): δ 8.66 (br s, 1H), 8.44 (d, J = 2.0 Hz, 1H), 7.89 (d, J = 2.7 Hz, 1H), 7.33 (d, J = 8.6 Hz, 1H), 7.24 (dd, J = 8.7, 2.4 Hz, 1H), 3.31 (hept, J = 6.8 Hz, 1H), 1.26 (d, J = 6.8 Hz, 6H). 13C-NMR (125 MHz, CDCl3): δ 200.4, 134.7, 131.4, 128.6, 127.0, 124.2, 122.3, 116.7, 112.2, 37.3, 19.6. GC-MS (EI, 70 eV): m/z (%) = 221 (25, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 244.0499, found 244.0537.
3-Propionyl-4-bromoindole
Molecules 20 19605 i022
Reddish brown solid, mp. 112–113 °C. 1H-NMR (500 MHz, CDCl3): δ 9.59 (br s, 1H), 7.40 (dt, J = 8.3, 0.8 Hz, 1H), 7.33 (dd, J = 7.5, 0.7 Hz, 1H), 7.24 (dd, J = 2.3, 0.9 Hz, 1H), 7.19 (dd, J = 8.2, 7.6 Hz, 1H), 3.04 (q, J = 7.4 Hz, 2H), 1.30 (t, J = 7.4 Hz, 3H). 13C-NMR (125 MHz, CDCl3): δ 194.1, 137.4, 135.0, 128.5, 126.8, 123.8, 116.8, 111.5, 108.9, 31.6, 8.6. GC-MS (EI, 70 eV): m/z (%) = 251 (70, [M+]). HR-ESI-MS: m/z calcd. for ([M + Na]+) 273.9838, found 273.9814.
3-Pivaloyl-4-bromoindole
Molecules 20 19605 i023
Pale yellow solid, mp = 154 °C. 1H-NMR (500 MHz, CDCl3): δ 9.37 (br s, 1H), 7.37 (d, J = 8.3 Hz, 1H), 7.32 (dd, J = 7.5, 0.6 Hz, 1H), 7.25 (dd, J = 2.3, 0.9 Hz, 1H), 7.17 (dd, J = 8.2, 7.6 Hz, 1H), 1.48 (s, 9H). 13C-NMR (125 MHz, CDCl3): δ 199.0, 136.1, 132.4, 128.7, 126.6, 123.7, 116.8, 111.2, 108.8, 43.5, 28.4. GC-MS (EI, 70 eV): m/z (%) = 279 (40, [M+]). HR-ESI-MS: m/z calcd for ([M + Na]+) 302.0151, found 302.0189.

4. Conclusions

In summary, a new catalytic system Y(OTf)3/[BMI]BF4 has been developed for 3-acylation of indoles using acid anhydrides under monomode microwave irradiation. This is a simple, straightforward and environmentally benign method to prepare 3-acylindoles in high yields, high regioselectivity and in short reaction times.

Acknowledgments

We thank Duy Khiem Nguyen Chau (University of Minnesota Duluth, Duluth, MN, USA) for helpful discussions.

Author Contributions

P. H. Tran, H. N. Tran designed and performed the experiments; P. E. Hansen and M. H. N. Do analyzed the spectra and data; P. H. Tran, P. E. Hansen and T. N. Le wrote the paper.

Conflicts of Interest

The authors declare no conflict of interest.

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  • Sample Availability: Samples of the compouns are available from the authors.

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Tran, P.H.; Tran, H.N.; Hansen, P.E.; Do, M.H.N.; Le, T.N. A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles. Molecules 2015, 20, 19605-19619. https://doi.org/10.3390/molecules201019605

AMA Style

Tran PH, Tran HN, Hansen PE, Do MHN, Le TN. A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles. Molecules. 2015; 20(10):19605-19619. https://doi.org/10.3390/molecules201019605

Chicago/Turabian Style

Tran, Phuong Hoang, Hai Ngoc Tran, Poul Erik Hansen, Mai Hoang Ngoc Do, and Thach Ngoc Le. 2015. "A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles" Molecules 20, no. 10: 19605-19619. https://doi.org/10.3390/molecules201019605

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