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Molecules 2015, 20(10), 19449-19462; doi:10.3390/molecules201019449

Selective Halogen-Lithium Exchange of 1,2-Dihaloarenes for Successive [2+4] Cycloadditions of Arynes and Isobenzofurans

Department of Applied Chemistry for Environment, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Hiroto Yoshida
Received: 1 October 2015 / Revised: 15 October 2015 / Accepted: 20 October 2015 / Published: 23 October 2015
(This article belongs to the Special Issue Development and Application of Aryne Chemistry in Organic Synthesis)
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Abstract

Successive [2+4] cycloadditions of arynes and isobenzofurans by site-selective halogen-lithium exchange of 1,2-dihaloarenes were developed, allowing the rapid construction of polycyclic compounds which serve as a useful synthetic intermediates for the preparation of various polyacene derivatives. View Full-Text
Keywords: aryne; isobenzofuran; [2+4] cycloaddition; 1,2-dihaloarenes; polyacene; halogen-lithium exchange aryne; isobenzofuran; [2+4] cycloaddition; 1,2-dihaloarenes; polyacene; halogen-lithium exchange
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Eda, S.; Hamura, T. Selective Halogen-Lithium Exchange of 1,2-Dihaloarenes for Successive [2+4] Cycloadditions of Arynes and Isobenzofurans. Molecules 2015, 20, 19449-19462.

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