The Multiple Roles of Microrna-223 in Regulating Bone Metabolism
AbstractBone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders. View Full-Text
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Xie, Y.; Zhang, L.; Gao, Y.; Ge, W.; Tang, P. The Multiple Roles of Microrna-223 in Regulating Bone Metabolism. Molecules 2015, 20, 19433-19448.
Xie Y, Zhang L, Gao Y, Ge W, Tang P. The Multiple Roles of Microrna-223 in Regulating Bone Metabolism. Molecules. 2015; 20(10):19433-19448.Chicago/Turabian Style
Xie, Yong; Zhang, Lihai; Gao, Yanpan; Ge, Wei; Tang, Peifu. 2015. "The Multiple Roles of Microrna-223 in Regulating Bone Metabolism." Molecules 20, no. 10: 19433-19448.