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Molecules 2015, 20(10), 19393-19405; doi:10.3390/molecules201019393

A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Authors to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 2 September 2015 / Revised: 16 October 2015 / Accepted: 16 October 2015 / Published: 23 October 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [781 KB, uploaded 23 October 2015]   |  


The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest. View Full-Text
Keywords: 1,4,7-triazonane; hydroxypyridinonate; metal chelator 1,4,7-triazonane; hydroxypyridinonate; metal chelator

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gai, Y.; Hu, Z.; Rong, Z.; Ma, X.; Xiang, G. A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm. Molecules 2015, 20, 19393-19405.

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