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Molecules 2015, 20(10), 18496-18510; doi:10.3390/molecules201018496

Anti-Inflammatory Constituents from Bidens frondosa

1
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2
College of Chemical and Biological Engineering, Yichun University, Jiangxi 336000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 August 2015 / Revised: 25 September 2015 / Accepted: 29 September 2015 / Published: 9 October 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [974 KB, uploaded 9 October 2015]   |  

Abstract

A new polyacetylene glucoside (3E,5E,11E)-tridecatriene-7,9-diyne-1,2,13-triol-2-O-β-d-glucopyranoside (1), a new phenylpropanoid glucoside 2′-butoxyethylconiferin (2), and a new flavonoid glycoside 8,3′,4′-trihydroxyflavone-7-O-(6′′-O-p-coumaroyl)-β-d-glucopyranoside (3), have been isolated from Bidens frondosa together with fifty-three known compounds 456. The structures of these compounds were established by spectroscopic methods. mainly ESIMS, 1D- and 2D-NMR spectroscopic data. and comparison with literature data. Compounds 134, 36, 39, 43, 47, 51, and 52 were tested for inhibition of nuclear factor kappa B (NF-κB) in 293-NF-κB-luciferase report cell line induced by lipopolysaccharide (LPS), and compounds 1, 2, 3, 9, 15, 21, 24 and 51 were tested for the production of TNF-α, IL-1β, IL-6, IL-10 in RAW 264.7 macrophages induced by LPS. In conclusion, the isolated compounds 1, 2, 3, 9, 15, 21, 24 and 51 exhibited significant activity in anti-inflammatory activity assays. View Full-Text
Keywords: Bidens frondosa; polyacetylene glucoside; phenylpropanoid glucoside; flavonoid glycoside; anti-inflammatory activity Bidens frondosa; polyacetylene glucoside; phenylpropanoid glucoside; flavonoid glycoside; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Le, J.; Lu, W.; Xiong, X.; Wu, Z.; Chen, W. Anti-Inflammatory Constituents from Bidens frondosa. Molecules 2015, 20, 18496-18510.

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