Anti-Inflammatory Constituents from Bidens frondosa
AbstractA new polyacetylene glucoside (3E,5E,11E)-tridecatriene-7,9-diyne-1,2,13-triol-2-O-β-d-glucopyranoside (1), a new phenylpropanoid glucoside 2′-butoxyethylconiferin (2), and a new flavonoid glycoside 8,3′,4′-trihydroxyflavone-7-O-(6′′-O-p-coumaroyl)-β-d-glucopyranoside (3), have been isolated from Bidens frondosa together with fifty-three known compounds 4–56. The structures of these compounds were established by spectroscopic methods. mainly ESIMS, 1D- and 2D-NMR spectroscopic data. and comparison with literature data. Compounds 1–34, 36, 39, 43, 47, 51, and 52 were tested for inhibition of nuclear factor kappa B (NF-κB) in 293-NF-κB-luciferase report cell line induced by lipopolysaccharide (LPS), and compounds 1, 2, 3, 9, 15, 21, 24 and 51 were tested for the production of TNF-α, IL-1β, IL-6, IL-10 in RAW 264.7 macrophages induced by LPS. In conclusion, the isolated compounds 1, 2, 3, 9, 15, 21, 24 and 51 exhibited significant activity in anti-inflammatory activity assays. View Full-Text
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Le, J.; Lu, W.; Xiong, X.; Wu, Z.; Chen, W. Anti-Inflammatory Constituents from Bidens frondosa. Molecules 2015, 20, 18496-18510.
Le J, Lu W, Xiong X, Wu Z, Chen W. Anti-Inflammatory Constituents from Bidens frondosa. Molecules. 2015; 20(10):18496-18510.Chicago/Turabian Style
Le, Jiamei; Lu, Wenquan; Xiong, Xiaojuan; Wu, Zhijun; Chen, Wansheng. 2015. "Anti-Inflammatory Constituents from Bidens frondosa." Molecules 20, no. 10: 18496-18510.