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Molecules 2015, 20(10), 17860-17871; doi:10.3390/molecules201017860

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

CSIRO Manufacturing Flagship, Bag 10, Clayton South, Victoria 3169, Australia
Author to whom correspondence should be addressed.
Academic Editor: Kerry Gilmore
Received: 25 August 2015 / Revised: 17 September 2015 / Accepted: 22 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Recent Advances in Flow Chemistry)
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Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers. View Full-Text
Keywords: continuous flow processing; flow chemistry; amination; process intensification continuous flow processing; flow chemistry; amination; process intensification

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kohl, T.M.; Hornung, C.H.; Tsanaktsidis, J. Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing. Molecules 2015, 20, 17860-17871.

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