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Molecules 2015, 20(1), 900-912; doi:10.3390/molecules20010900

The Role of Selected Flavonols in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor–1 (TRAIL-R1) Expression on Activated RAW 264.7 Macrophages

1
School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Chair and Department of Microbiology and Immunology, Jordana 19, 41-808 Zabrze, Poland
2
School of Public Health in Bytom, Medical University of Silesia in Katowice, Toxicology and Drug Addiction Division, Communal Department of Hygiene and Sanitary Supervision, Medyków 18, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 24 November 2014 / Accepted: 5 January 2015 / Published: 8 January 2015
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Abstract

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptors (TRAIL-R) are an important factor of apoptosis in cancer cells. There are no data about the effect of flavonols on the receptor expression on a surface of macrophage like cells. In this study, the expression level of TRAIL-R1 on murine RAW264.7 macrophages in the presence of selected flavonols: galangin, kaempferol, kaempferide and quercetin, which differ from their phenyl ring substituents, were studied. The expression of TRAIL-R1 death receptors on non-stimulated and lipopolysaccharide (LPS)-stimulated macrophages was determined using flow cytometry. The results suggested that compounds being tested can modulate TRAIL-R1 expression and can enhance TRAIL-mediated apoptosis. View Full-Text
Keywords: galangin; kaempferol; kaempferide; quercetin; Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand)-Receptor (TRAIL-R1) expression; RAW264.7 macrophages galangin; kaempferol; kaempferide; quercetin; Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand)-Receptor (TRAIL-R1) expression; RAW264.7 macrophages
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Warat, M.; Sadowski, T.; Szliszka, E.; Król, W.; Czuba, Z.P. The Role of Selected Flavonols in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor–1 (TRAIL-R1) Expression on Activated RAW 264.7 Macrophages. Molecules 2015, 20, 900-912.

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