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Molecules 2015, 20(1), 430-445; doi:10.3390/molecules20010430

An Effective Vacuum Assisted Extraction Method for the Optimization of Labdane Diterpenoids from Andrographis paniculata by Response Surface Methodology

Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 November 2014 / Accepted: 23 December 2014 / Published: 31 December 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [4254 KB, uploaded 31 December 2014]   |  

Abstract

An effective vacuum assisted extraction (VAE) technique was proposed for the first time and applied to extract bioactive components from Andrographis paniculata. The process was carefully optimized by response surface methodology (RSM). Under the optimized experimental conditions, the best results were obtained using a boiling temperature of 65 °C, 50% ethanol concentration, 16 min of extraction time, one extraction cycles and a 12:1 liquid-solid ratio. Compared with conventional ultrasonic assisted extraction and heat reflux extraction, the VAE technique gave shorter extraction times and remarkable higher extraction efficiency, which indicated that a certain degree of vacuum gave the solvent a better penetration of the solvent into the pores and between the matrix particles, and enhanced the process of mass transfer. The present results demonstrated that VAE is an efficient, simple and fast method for extracting bioactive components from A. paniculata, which shows great potential for becoming an alternative technique for industrial scale-up applications. View Full-Text
Keywords: andrographolide; dehydroandrographolide; Andrographis paniculata; vacuum assisted extraction; response surface methodology (RSM) andrographolide; dehydroandrographolide; Andrographis paniculata; vacuum assisted extraction; response surface methodology (RSM)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, Y.-Q.; Wu, Z.-F.; Ke, G.; Yang, M. An Effective Vacuum Assisted Extraction Method for the Optimization of Labdane Diterpenoids from Andrographis paniculata by Response Surface Methodology. Molecules 2015, 20, 430-445.

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