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Molecules 2014, 19(9), 14794-14808; doi:10.3390/molecules190914794

Enhanced Antioxidant Capacity and Anti-Ageing Biomarkers after Diet Micronutrient Supplementation

1
Department of Molecular Biophysics, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland
2
Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8/10, Lodz 92-216, Poland
3
Department of Medical Biochemistry, Medical University in Lodz, Mazowiecka 6/8, Lodz 92-215, Poland
*
Author to whom correspondence should be addressed.
Received: 17 July 2014 / Revised: 3 September 2014 / Accepted: 9 September 2014 / Published: 17 September 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Abstract

A growing number of studies confirm an important effect of diet, lifestyle and physical activity on health status, the ageing process and many metabolic disorders. This study focuses on the influence of a diet supplement, NucleVital®Q10 Complex, on parameters related to redox homeostasis and ageing. An experimental group of 66 healthy volunteer women aged 35–55 supplemented their diet for 12 weeks with the complex, which contained omega-3 acids (1350 mg/day), ubiquinone (300 mg/day), astaxanthin (15 mg/day), lycopene (45 mg/day), lutein palmitate (30 mg/day), zeaxanthine palmitate (6 mg/day), L-selenomethionine (330 mg/day), cholecalciferol (30 µg/day) and α-tocopherol (45 mg/day). We found that NucleVital®Q10 Complex supplementation significantly increased total antioxidant capacity of plasma and activity of erythrocyte superoxide dismutase, with slight effects on oxidative stress biomarkers in erythrocytes; MDA and 4-hydroxyalkene levels. Apart from the observed antioxidative effects, the tested supplement also showed anti-ageing activity. Analysis of expression of SIRT1 and 2 in PBMCs showed significant changes for both genes on a mRNA level. The level of telomerase was also increased by more than 25%, although the length of lymphocyte telomeres, determined by RT-PCR, remained unchanged. Our results demonstrate beneficial effects concerning the antioxidant potential of plasma as well as biomarkers related to ageing even after short term supplementation of diet with NucleVital®Q10 Complex. View Full-Text
Keywords: antioxidants; redox homeostasis; ageing; diet supplements antioxidants; redox homeostasis; ageing; diet supplements
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MDPI and ACS Style

Balcerczyk, A.; Gajewska, A.; Macierzyńska-Piotrowska, E.; Pawelczyk, T.; Bartosz, G.; Szemraj, J. Enhanced Antioxidant Capacity and Anti-Ageing Biomarkers after Diet Micronutrient Supplementation. Molecules 2014, 19, 14794-14808.

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