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Molecules 2014, 19(9), 14461-14483; doi:10.3390/molecules190914461

Native Chemical Ligation: A Boon to Peptide Chemistry

Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA
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Received: 31 July 2014 / Revised: 2 September 2014 / Accepted: 2 September 2014 / Published: 12 September 2014
(This article belongs to the Special Issue Peptide Chemistry)
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Abstract

The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the entry of peptides into the world of viable oral therapeutic drugs through peptide backbone cyclization. This progression has been a journey of chemical exploration and transition, leading to the dominance of native chemical ligation in the present advances of peptide/protein applications. Here we illustrate and explore the historical and current nature of peptide ligation, providing a clear indication to the possibilities and use of these novel methods to take peptides outside their typically defined boundaries. View Full-Text
Keywords: native chemical ligation; cyclotides; conotoxin; convergent; sequential; auxiliary; thioester native chemical ligation; cyclotides; conotoxin; convergent; sequential; auxiliary; thioester
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Thapa, P.; Zhang, R.-Y.; Menon, V.; Bingham, J.-P. Native Chemical Ligation: A Boon to Peptide Chemistry. Molecules 2014, 19, 14461-14483.

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