A One-Pot Approach to Pyridyl Isothiocyanates from Amines
AbstractA one-pot preparation of pyridyl isothiocyanates (ITCs) from their corresponding amines has been developed. This method involves aqueous iron(III) chloride-mediated desulfurization of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide in the present of DABCO or sodium hydride. The choice of base is of decisive importance for the formation of the dithiocarbamate salts. This one-pot process works well for a wide range of pyridyl ITCs. Utilizing this protocol, some highly electron-deficient pyridyl and aryl ITCs are obtained in moderate to good yields. View Full-Text
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Zhang, H.; Liu, R.-Q.; Liu, K.-C.; Li, Q.-B.; Li, Q.-Y.; Liu, S.-Z. A One-Pot Approach to Pyridyl Isothiocyanates from Amines. Molecules 2014, 19, 13631-13642.
Zhang H, Liu R-Q, Liu K-C, Li Q-B, Li Q-Y, Liu S-Z. A One-Pot Approach to Pyridyl Isothiocyanates from Amines. Molecules. 2014; 19(9):13631-13642.Chicago/Turabian Style
Zhang, Hao; Liu, Rui-Quan; Liu, Ke-Chang; Li, Qi-Bo; Li, Qing-Yang; Liu, Shang-Zhong. 2014. "A One-Pot Approach to Pyridyl Isothiocyanates from Amines." Molecules 19, no. 9: 13631-13642.