Next Article in Journal
Peptides Derived from Rhopilema esculentum Hydrolysate Exhibit Angiotensin Converting Enzyme (ACE) Inhibitory and Antioxidant Abilities
Previous Article in Journal
Effects of Heat Acclimation on Photosynthesis, Antioxidant Enzyme Activities, and Gene Expression in Orchardgrass under Heat Stress
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 13577-13586; doi:10.3390/molecules190913577

Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one

1
Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam
2
Department of Chemistry, Vinh University, Vinh 42000, Vietnam
3
Department of Biotechnology, National Formosa University, Yunlin 63201, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 26 August 2014 / Accepted: 27 August 2014 / Published: 1 September 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [708 KB, uploaded 1 September 2014]   |  

Abstract

In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5ah. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5ah were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria. View Full-Text
Keywords: coumarin; 2-thioxo-1,3-thiazolidin-4-one; spectral elucidation; antibacterial activity coumarin; 2-thioxo-1,3-thiazolidin-4-one; spectral elucidation; antibacterial activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cong, N.T.; Nhan, H.T.; Van Hung, L.; Thang, T.D.; Kuo, P.-C. Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one. Molecules 2014, 19, 13577-13586.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top