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Molecules 2014, 19(9), 13225-13234; doi:10.3390/molecules190913225
Article

Cytotoxic Compounds Isolated from Murraya tetramera Huang

1,2
, 1,2
, 1,3
, 1,2
, 1,2
, 4
, 3,* , 1,2,* , 4
 and 4
Received: 21 July 2014; in revised form: 21 August 2014 / Accepted: 21 August 2014 / Published: 27 August 2014
(This article belongs to the collection Bioactive Compounds)
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Abstract: A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methyl-butan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer.
Keywords: M. tetramera; cytotoxicity; coumarin; sesquiterpene M. tetramera; cytotoxicity; coumarin; sesquiterpene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

You, C.-X.; Yang, K.; Wang, C.-F.; Zhang, W.-J.; Wang, Y.; Han, J.; Fan, L.; Du, S.-S.; Geng, Z.-F.; Deng, Z.-W. Cytotoxic Compounds Isolated from Murraya tetramera Huang. Molecules 2014, 19, 13225-13234.

AMA Style

You C-X, Yang K, Wang C-F, Zhang W-J, Wang Y, Han J, Fan L, Du S-S, Geng Z-F, Deng Z-W. Cytotoxic Compounds Isolated from Murraya tetramera Huang. Molecules. 2014; 19(9):13225-13234.

Chicago/Turabian Style

You, Chun-Xue; Yang, Kai; Wang, Cheng-Fang; Zhang, Wen-Juan; Wang, Ying; Han, Jiao; Fan, Li; Du, Shu-Shan; Geng, Zhu-Feng; Deng, Zhi-Wei. 2014. "Cytotoxic Compounds Isolated from Murraya tetramera Huang." Molecules 19, no. 9: 13225-13234.


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