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Molecules 2014, 19(8), 12814-12826; doi:10.3390/molecules190812814

Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
2
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, Brazil
3
Laboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, R. José Lourenço Kelmer s/n, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
*
Authors to whom correspondence should be addressed.
Received: 16 May 2014 / Revised: 8 August 2014 / Accepted: 13 August 2014 / Published: 21 August 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H2O2, TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H2O2, NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG35–55 stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells. View Full-Text
Keywords: multiple sclerosis; experimental autoimmune encephalomyelitis; natural products; immunomodulatory; copaiba oil multiple sclerosis; experimental autoimmune encephalomyelitis; natural products; immunomodulatory; copaiba oil
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MDPI and ACS Style

Dias, D.S.; Fontes, L.B.A.; Crotti, A.E.M.; Aarestrup, B.J.V.; Aarestrup, F.M.; da Silva Filho, A.A.; Corrêa, J.O.A. Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE). Molecules 2014, 19, 12814-12826.

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