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Molecules 2014, 19(8), 12630-12639; doi:10.3390/molecules190812630

Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

1
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
2
Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
*
Author to whom correspondence should be addressed.
Received: 7 May 2014 / Revised: 14 June 2014 / Accepted: 30 July 2014 / Published: 19 August 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects. View Full-Text
Keywords: methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism
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MDPI and ACS Style

Su, Y.; Ma, L.; Wen, Y.; Wang, H.; Zhang, S. Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus. Molecules 2014, 19, 12630-12639.

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