68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression
AbstractPeptides containing the asparagines-glycine-arginine (NGR) motif have been identified as specific ligands binding to CD13/aminopeptidase N (APN) receptor, a tumor neovascular biomarker. In this study, we synthesized a novel NGR-containing peptide (NOTA-G3-NGR), and labeled NOTA-G3-NGR with 68Ga (t1/2 = 67.7 min). The resulting 68Ga-NOTA-G3-NGR peptide was subject to in vitro and in vivo characterization. The microPET imaging results revealed that the 68Ga-NOTA-G3-NGR peptide exhibits rapid and specific tumor uptake, and high tumor-to-background contrast in a subcutaneous HT-1080 fibrosarcoma mouse model. We concluded that the 68Ga-NOTA-G3-NGR peptide has potential in the diagnosis of CD13-targeted tumor angiogenesis. View Full-Text
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Shao, Y.; Liang, W.; Kang, F.; Yang, W.; Ma, X.; Li, G.; Zong, S.; Chen, K.; Wang, J. 68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression. Molecules 2014, 19, 11600-11612.
Shao Y, Liang W, Kang F, Yang W, Ma X, Li G, Zong S, Chen K, Wang J. 68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression. Molecules. 2014; 19(8):11600-11612.Chicago/Turabian Style
Shao, Yahui; Liang, Wansheng; Kang, Fei; Yang, Weidong; Ma, Xiaowei; Li, Guiyu; Zong, Shu; Chen, Kai; Wang, Jing. 2014. "68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression." Molecules 19, no. 8: 11600-11612.