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Molecules 2014, 19(8), 11505-11519; doi:10.3390/molecules190811505

Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy
Authors to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 15 July 2014 / Accepted: 21 July 2014 / Published: 4 August 2014
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [763 KB, uploaded 4 August 2014]   |  


By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. View Full-Text
Keywords: aziridines; boron compounds; Suzuki-Miyaura; palladium coupling; antibiotics aziridines; boron compounds; Suzuki-Miyaura; palladium coupling; antibiotics

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Giovine, A.; Muraglia, M.; Florio, M.A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R. Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents. Molecules 2014, 19, 11505-11519.

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