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Molecules 2014, 19(7), 9552-9561; doi:10.3390/molecules19079552

Formation of a Flavin-Linked Peptide

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan
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Received: 27 May 2014 / Revised: 2 July 2014 / Accepted: 2 July 2014 / Published: 4 July 2014
(This article belongs to the Special Issue ECSOC-17)
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Abstract

In a previous study, we showed that formylmethylflavin (FMF) can bind to cysteine. In this study, FMF was reacted with native peptides (CG and CKLVFF) containing an N-terminal cysteine. The formation of flavin-CG and flavin-CKLVFF was confirmed using HPLC and ESI-MS. Storage of flavin-CKLVFF in DMSO at −30 °C for 7 days resulted in no detectable deposition. In contrast, flavin-CKLVFF formed deposits when stored in water at −30 °C for 1 day, but no deposit was observed in the aqueous solution of flavin-CKLVFF after 7 days storage in the presence of 0.1% Triton X-100. View Full-Text
Keywords: flavin; peptide; cysteine; aldehyde; Aβ peptide flavin; peptide; cysteine; aldehyde; Aβ peptide
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Morikawa, M.; Kino, K.; Senda, T.; Suzuki, M.; Kobayashi, T.; Miyazawa, H. Formation of a Flavin-Linked Peptide. Molecules 2014, 19, 9552-9561.

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