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Molecules 2014, 19(7), 9552-9561; doi:10.3390/molecules19079552
Article

Formation of a Flavin-Linked Peptide

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Received: 27 May 2014; in revised form: 2 July 2014 / Accepted: 2 July 2014 / Published: 4 July 2014
(This article belongs to the Special Issue ECSOC-17)
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Abstract: In a previous study, we showed that formylmethylflavin (FMF) can bind to cysteine. In this study, FMF was reacted with native peptides (CG and CKLVFF) containing an N-terminal cysteine. The formation of flavin-CG and flavin-CKLVFF was confirmed using HPLC and ESI-MS. Storage of flavin-CKLVFF in DMSO at −30 °C for 7 days resulted in no detectable deposition. In contrast, flavin-CKLVFF formed deposits when stored in water at −30 °C for 1 day, but no deposit was observed in the aqueous solution of flavin-CKLVFF after 7 days storage in the presence of 0.1% Triton X-100.
Keywords: flavin; peptide; cysteine; aldehyde; Aβ peptide flavin; peptide; cysteine; aldehyde; Aβ peptide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Morikawa, M.; Kino, K.; Senda, T.; Suzuki, M.; Kobayashi, T.; Miyazawa, H. Formation of a Flavin-Linked Peptide. Molecules 2014, 19, 9552-9561.

AMA Style

Morikawa M, Kino K, Senda T, Suzuki M, Kobayashi T, Miyazawa H. Formation of a Flavin-Linked Peptide. Molecules. 2014; 19(7):9552-9561.

Chicago/Turabian Style

Morikawa, Masayuki; Kino, Katsuhito; Senda, Takeshi; Suzuki, Masayo; Kobayashi, Takanobu; Miyazawa, Hiroshi. 2014. "Formation of a Flavin-Linked Peptide." Molecules 19, no. 7: 9552-9561.


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