Molecules 2014, 19(7), 9552-9561; doi:10.3390/molecules19079552

Formation of a Flavin-Linked Peptide

email, * email, email, email, email and email
Received: 27 May 2014; in revised form: 2 July 2014 / Accepted: 2 July 2014 / Published: 4 July 2014
(This article belongs to the Special Issue ECSOC-17)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In a previous study, we showed that formylmethylflavin (FMF) can bind to cysteine. In this study, FMF was reacted with native peptides (CG and CKLVFF) containing an N-terminal cysteine. The formation of flavin-CG and flavin-CKLVFF was confirmed using HPLC and ESI-MS. Storage of flavin-CKLVFF in DMSO at −30 °C for 7 days resulted in no detectable deposition. In contrast, flavin-CKLVFF formed deposits when stored in water at −30 °C for 1 day, but no deposit was observed in the aqueous solution of flavin-CKLVFF after 7 days storage in the presence of 0.1% Triton X-100.
Keywords: flavin; peptide; cysteine; aldehyde; Aβ peptide
PDF Full-text Download PDF Full-Text [501 KB, uploaded 4 July 2014 13:08 CEST]

Export to BibTeX |

MDPI and ACS Style

Morikawa, M.; Kino, K.; Senda, T.; Suzuki, M.; Kobayashi, T.; Miyazawa, H. Formation of a Flavin-Linked Peptide. Molecules 2014, 19, 9552-9561.

AMA Style

Morikawa M, Kino K, Senda T, Suzuki M, Kobayashi T, Miyazawa H. Formation of a Flavin-Linked Peptide. Molecules. 2014; 19(7):9552-9561.

Chicago/Turabian Style

Morikawa, Masayuki; Kino, Katsuhito; Senda, Takeshi; Suzuki, Masayo; Kobayashi, Takanobu; Miyazawa, Hiroshi. 2014. "Formation of a Flavin-Linked Peptide." Molecules 19, no. 7: 9552-9561.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert