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Molecules 2014, 19(7), 9339-9353; doi:10.3390/molecules19079339

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

1
Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy
2
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli "Federico II", via Cintia, 21, 80126 Napoli, Italy
3
INSERM U848, IGR, 39 rue C. Desmoulins, 94805 Villejuif, France
*
Author to whom correspondence should be addressed.
Received: 26 March 2014 / Revised: 23 June 2014 / Accepted: 25 June 2014 / Published: 3 July 2014
(This article belongs to the Special Issue Practical Applications of Metal Complexes)
View Full-Text   |   Download PDF [392 KB, uploaded 3 July 2014]   |  

Abstract

The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation. View Full-Text
Keywords: platinum complexes; nucleosides; cisplatin; chemotherapy platinum complexes; nucleosides; cisplatin; chemotherapy
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MDPI and ACS Style

D'Errico, S.; Oliviero, G.; Borbone, N.; Piccialli, V.; Pinto, B.; De Falco, F.; Maiuri, M.C.; Carnuccio, R.; Costantino, V.; Nici, F.; Piccialli, G. Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties. Molecules 2014, 19, 9339-9353.

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