Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards
AbstractA series of N-mustards, which was conjugated to mono- or bis-naphthalimides with a flexible amine link, were synthesized and evaluated for cytotoxicity against five cancer cell lines (HCT-116, PC-3, U87 MG, Hep G2 and SK-OV-3). Several compounds displayed better activities than the control compound amonafide. Further evaluations by fluorescence spectroscopy studies and DNA-interstrand cross-linking assays revealed that the derivatives showed both alkylating and intercalating properties. Among the derivatives, the bis-naphthalimide N-mustard derivative 11b was found to exhibit the highest cytotoxic activity and DNA cross-linking ability. Both 11b and 7b induce HCT-116 cell apoptosis by S phase arrest. View Full-Text
- Supplementary File 1:
Supporting Information (PDF, 1066 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lou, Q.; Ji, L.; Zhong, W.; Li, S.; Yu, S.; Li, Z.; Meng, X. Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards. Molecules 2014, 19, 8803-8819.
Lou Q, Ji L, Zhong W, Li S, Yu S, Li Z, Meng X. Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards. Molecules. 2014; 19(7):8803-8819.Chicago/Turabian Style
Lou, Qinghua; Ji, Liyan; Zhong, Wenhe; Li, Shasha; Yu, Siwang; Li, Zhongjun; Meng, Xiangbao. 2014. "Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards." Molecules 19, no. 7: 8803-8819.