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Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer
AbstractStructural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
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Thakur, M.S.; Khurana, A.; Kronenberg, M.; Howell, A.R. Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer. Molecules 2014, 19, 10090-10102.View more citation formats
Thakur MS, Khurana A, Kronenberg M, Howell AR. Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer. Molecules. 2014; 19(7):10090-10102.Chicago/Turabian Style
Thakur, Meena S.; Khurana, Archana; Kronenberg, Mitchell; Howell, Amy R. 2014. "Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer." Molecules 19, no. 7: 10090-10102.