Molecules 2014, 19(7), 10090-10102; doi:10.3390/molecules190710090
Article

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

1, 2, 2 and 1,* email
Received: 29 May 2014; in revised form: 25 June 2014 / Accepted: 30 June 2014 / Published: 10 July 2014
(This article belongs to the Special Issue Synthesis, Structure, Analysis and Properties of Glycolipids)
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Abstract: Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
Keywords: β-GalCer; antigens; NKT cells; CD1d
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Thakur, M.S.; Khurana, A.; Kronenberg, M.; Howell, A.R. Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer. Molecules 2014, 19, 10090-10102.

AMA Style

Thakur MS, Khurana A, Kronenberg M, Howell AR. Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer. Molecules. 2014; 19(7):10090-10102.

Chicago/Turabian Style

Thakur, Meena S.; Khurana, Archana; Kronenberg, Mitchell; Howell, Amy R. 2014. "Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer." Molecules 19, no. 7: 10090-10102.


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