Next Article in Journal
Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes
Previous Article in Journal
Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway
Previous Article in Special Issue
Gold Nanoparticles Decorated with Mannose-6-phosphate Analogues
Molecules 2014, 19(7), 10090-10102; doi:10.3390/molecules190710090

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

1, 2, 2 and 1,*
1 Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA 2 La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
* Author to whom correspondence should be addressed.
Received: 29 May 2014 / Revised: 25 June 2014 / Accepted: 30 June 2014 / Published: 10 July 2014
(This article belongs to the Special Issue Synthesis, Structure, Analysis and Properties of Glycolipids)
View Full-Text   |   Download PDF [320 KB, uploaded 10 July 2014]   |   Browse Figures


Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
Keywords: β-GalCer; antigens; NKT cells; CD1d β-GalCer; antigens; NKT cells; CD1d
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Thakur, M.S.; Khurana, A.; Kronenberg, M.; Howell, A.R. Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer. Molecules 2014, 19, 10090-10102.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert