α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume
AbstractPolyphenol extracts from the burs of Castanea mollissima Blume (CMPE) exhibited potential antioxidant and hypoglycemic activities. The α-glucosidase inhibitory activities of CMPE were assessed as a means of elucidating the mechanism behind its hypoglycemic activities. In vitro studies showed that CMPE significantly inhibited both yeast α-glucosidase, through a noncompetitive mode with an IC50 of 0.33 μg/mL, and rat intestinal α-glucosidase. In vivo studies revealed that oral administration of CMPE at doses of 600 mg/kg significantly reduced postprandial blood glucose levels by 27.2% in normal rats following sucrose challenges. Gel permeation chromatography revealed that CMPE exhibited typical characteristics of high-molecular-mass polymers with mean (Mn) and weight (Mw) average molecular weights of 35.4 and 50.7 kDa, respectively, and a polydispersity (Mw/Mn) of 1.432. Acid hydrolysis analysis indicated the presence of ellagitannins. These data suggest that CMPE, enriched with ellagitannins, would be an efficacious dietary supplement for diabetes management through the inhibition of alpha-glucosidase. View Full-Text
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Zhang, J.; Zhao, S.; Yin, P.; Yan, L.; Han, J.; Shi, L.; Zhou, X.; Liu, Y.; Ma, C. α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume. Molecules 2014, 19, 8373-8386.
Zhang J, Zhao S, Yin P, Yan L, Han J, Shi L, Zhou X, Liu Y, Ma C. α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume. Molecules. 2014; 19(6):8373-8386.Chicago/Turabian Style
Zhang, Jianwei; Zhao, Shan; Yin, Peipei; Yan, Linlin; Han, Jin; Shi, Lingling; Zhou, Xiaojing; Liu, Yujun; Ma, Chao. 2014. "α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume." Molecules 19, no. 6: 8373-8386.