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Molecules 2014, 19(6), 8373-8386; doi:10.3390/molecules19068373

α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume

1
National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China
2
Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China
3
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
4
State Academy of Forestry Administration, Beijing 102600, China
*
Authors to whom correspondence should be addressed.
Received: 15 April 2014 / Revised: 30 May 2014 / Accepted: 9 June 2014 / Published: 19 June 2014
(This article belongs to the Section Natural Products)
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Abstract

Polyphenol extracts from the burs of Castanea mollissima Blume (CMPE) exhibited potential antioxidant and hypoglycemic activities. The α-glucosidase inhibitory activities of CMPE were assessed as a means of elucidating the mechanism behind its hypoglycemic activities. In vitro studies showed that CMPE significantly inhibited both yeast α-glucosidase, through a noncompetitive mode with an IC50 of 0.33 μg/mL, and rat intestinal α-glucosidase. In vivo studies revealed that oral administration of CMPE at doses of 600 mg/kg significantly reduced postprandial blood glucose levels by 27.2% in normal rats following sucrose challenges. Gel permeation chromatography revealed that CMPE exhibited typical characteristics of high-molecular-mass polymers with mean (Mn) and weight (Mw) average molecular weights of 35.4 and 50.7 kDa, respectively, and a polydispersity (Mw/Mn) of 1.432. Acid hydrolysis analysis indicated the presence of ellagitannins. These data suggest that CMPE, enriched with ellagitannins, would be an efficacious dietary supplement for diabetes management through the inhibition of alpha-glucosidase. View Full-Text
Keywords: Castanea mollissima Blume; polyphenols; α-glucosidase; diabetic; ellagitannins Castanea mollissima Blume; polyphenols; α-glucosidase; diabetic; ellagitannins
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Zhang, J.; Zhao, S.; Yin, P.; Yan, L.; Han, J.; Shi, L.; Zhou, X.; Liu, Y.; Ma, C. α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume. Molecules 2014, 19, 8373-8386.

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