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Molecules 2014, 19(6), 7207-7222; doi:10.3390/molecules19067207

Post-Harvest Induced Production of Salvianolic Acids and Significant Promotion of Antioxidant Properties in Roots of Salvia miltiorrhiza (Danshen)

1
Research Center of Natural Products, Institute of Plant Biology, Fudan University, Shanghai 200433, China
2
Department of Resources Science of Traditional Chinese Medicines & Key Laboratory of Modern Chinese Medicines (Ministry of Education), China Pharmaceutical University, Nanjing 210009, China
3
School of Traditional Chinese Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, China
*
Author to whom correspondence should be addressed.
Received: 29 April 2014 / Revised: 23 May 2014 / Accepted: 27 May 2014 / Published: 30 May 2014
(This article belongs to the Section Natural Products)
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Abstract

Danshen, the dried roots of Salvia miltiorrhiza, is an extremely valued Traditional Chinese Medicine. Previously, we have demonstrated that salvianolic acid B (SaB), the important bioactive ingredient in this herb, was a post-harvest product. Here, we further reported that all salvianolic acids (SAs) in the roots were post-harvest products of the drying process. In addition, the results of various radical scavenging activity assays, including lipid peroxidation (1), DPPH (2), hydroxyl (3) and superoxide (4), were significantly increased along with the accumulation of total salvianolic acids in the process. The contents of chemical targets and antioxidant activities both reached the highest value under thermal treatment at 130 °C for 80 min. In this dehydration period, contents of SaB, and sum of nine SAs increased from 0.01% to 5.51%, and 0.20% to 6.61%; and IC50 of antioxidant activity decreased from 4.85 to 2.69 (1); 7.75 to 0.43 (2); 2.57 to 1.13 (3) and 17.25 to 1.10 mg/mL. These results further supported the hypothesis that the newly harvested plant roots were still physiologically active and the secondary metabolites might be produced due to dehydration stress after harvest. Our findings supplied an important and useful theoretical basis for promoting the quality of Danshen and other medicinal plant materials. View Full-Text
Keywords: accumulation after harvest; dehydration inducement; radical scavenging activity; Salvia miltiorrhiza; salvianolic acid B accumulation after harvest; dehydration inducement; radical scavenging activity; Salvia miltiorrhiza; salvianolic acid B
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MDPI and ACS Style

Zhou, G.-J.; Wang, W.; Xie, X.-M.; Qin, M.-J.; Kuai, B.-K.; Zhou, T.-S. Post-Harvest Induced Production of Salvianolic Acids and Significant Promotion of Antioxidant Properties in Roots of Salvia miltiorrhiza (Danshen). Molecules 2014, 19, 7207-7222.

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