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Molecules 2014, 19(6), 7138-7151; doi:10.3390/molecules19067138

Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats

Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea
Authors to whom correspondence should be addressed.
Received: 10 April 2014 / Revised: 26 May 2014 / Accepted: 28 May 2014 / Published: 30 May 2014
(This article belongs to the Section Natural Products)
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Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe. View Full-Text
Keywords: Cirsium setidens; oral administration; safety; toxicity Cirsium setidens; oral administration; safety; toxicity

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, J.S.; Kim, Y.-H.; Kim, D.-B.; Bang, W.-S.; Lee, O.-H. Acute and 4-Week Repeated-Dose Oral Toxicity Studies of Cirsium setidens in Rats. Molecules 2014, 19, 7138-7151.

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