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Molecules 2014, 19(6), 6987-7007; doi:10.3390/molecules19066987
Review

Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines

1, 1, 1, 1, 1, 2 and 1,*
Received: 28 February 2014; in revised form: 13 May 2014 / Accepted: 21 May 2014 / Published: 28 May 2014
(This article belongs to the Special Issue Ruthenium Complex)
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Abstract: The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(η6-arene)(N-arylsulfonyl-DPEN)] (DPEN = 1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the catalysts in terms of its interaction with protonated imines (substrates) and amines (components of the hydrogen-donor mixture). The second part is oriented toward the role of the η6-coordinated arene. The final part concerns the imine substrate structural modifications and their importance in connection with ATH. Throughout the text, the summary of known findings is complemented with newly-presented ones, which have been approached both experimentally and computationally.
Keywords: ruthenium; asymmetric hydrogenation; imine; ligand; sulfonyl; arene; DFT ruthenium; asymmetric hydrogenation; imine; ligand; sulfonyl; arene; DFT
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Václavík, J.; Šot, P.; Pecháček, J.; Vilhanová, B.; Matuška, O.; Kuzma, M.; Kačer, P. Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines. Molecules 2014, 19, 6987-7007.

AMA Style

Václavík J, Šot P, Pecháček J, Vilhanová B, Matuška O, Kuzma M, Kačer P. Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines. Molecules. 2014; 19(6):6987-7007.

Chicago/Turabian Style

Václavík, Jiří; Šot, Petr; Pecháček, Jan; Vilhanová, Beáta; Matuška, Ondřej; Kuzma, Marek; Kačer, Petr. 2014. "Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines." Molecules 19, no. 6: 6987-7007.


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