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Molecules 2014, 19(5), 6597-6608; doi:10.3390/molecules19056597
Article

Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

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Received: 14 March 2014; in revised form: 14 May 2014 / Accepted: 19 May 2014 / Published: 22 May 2014
(This article belongs to the Section Metabolites)
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Abstract: Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
Keywords: secondary metabolites; bioactivities; endophytic fungi; Phomopsis sp.; Senna spectabilis secondary metabolites; bioactivities; endophytic fungi; Phomopsis sp.; Senna spectabilis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chapla, V.M.; Zeraik, M.L.; Ximenes, V.F.; Zanardi, L.M.; Lopes, M.N.; Cavalheiro, A.J.; Silva, D.H.S.; Young, M.C.M.; Fonseca, L.M.; Bolzani, V.S.; Araújo, A.R. Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis. Molecules 2014, 19, 6597-6608.

AMA Style

Chapla VM, Zeraik ML, Ximenes VF, Zanardi LM, Lopes MN, Cavalheiro AJ, Silva DHS, Young MCM, Fonseca LM, Bolzani VS, Araújo AR. Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis. Molecules. 2014; 19(5):6597-6608.

Chicago/Turabian Style

Chapla, Vanessa M.; Zeraik, Maria L.; Ximenes, Valdecir F.; Zanardi, Lisinéia M.; Lopes, Márcia N.; Cavalheiro, Alberto J.; Silva, Dulce H.S.; Young, Maria C.M.; Fonseca, Luiz M.; Bolzani, Vanderlan S.; Araújo, Angela R. 2014. "Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis." Molecules 19, no. 5: 6597-6608.


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