Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
AbstractChemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
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Chapla, V.M.; Zeraik, M.L.; Ximenes, V.F.; Zanardi, L.M.; Lopes, M.N.; Cavalheiro, A.J.; Silva, D.H.S.; Young, M.C.M.; Fonseca, L.M.; Bolzani, V.S.; Araújo, A.R. Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis. Molecules 2014, 19, 6597-6608.
Chapla VM, Zeraik ML, Ximenes VF, Zanardi LM, Lopes MN, Cavalheiro AJ, Silva DHS, Young MCM, Fonseca LM, Bolzani VS, Araújo AR. Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis. Molecules. 2014; 19(5):6597-6608.Chicago/Turabian Style
Chapla, Vanessa M.; Zeraik, Maria L.; Ximenes, Valdecir F.; Zanardi, Lisinéia M.; Lopes, Márcia N.; Cavalheiro, Alberto J.; Silva, Dulce H.S.; Young, Maria C.M.; Fonseca, Luiz M.; Bolzani, Vanderlan S.; Araújo, Angela R. 2014. "Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis." Molecules 19, no. 5: 6597-6608.