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Molecules 2014, 19(5), 5940-5951; doi:10.3390/molecules19055940
Article

Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.

1,2,* , 2 and 2
1 Department of Pharmacognosy, College of Pharmacy, King Saud University (KSU), Riyadh 11451, Kingdom of Saudi Arabia 2 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt
* Author to whom correspondence should be addressed.
Received: 20 March 2014 / Revised: 23 April 2014 / Accepted: 4 May 2014 / Published: 9 May 2014
(This article belongs to the Section Natural Products)
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Abstract

A phytochemical investigation of the least polar organic extracts of Arnebia hispidissima (Lehm.) DC. roots has led to the isolation of two unique polycyclic geranylhydroquinone-derived metabolites, arnebacene (1) and arnebidin (2), along with some known phenolic metabolites viz., arnebin-7 (3) and vanillic acid (4). The chemical identification of the new isolated compounds, including their relative stereochemistry, was achieved via spectroscopic analyses, including 2D NMR, and spectral comparison with related compounds. A biosynthetic pathway is proposed for the new compounds on the basis of their structure-relationship with previously isolated metabolites.
Keywords: Arnebia hispidissima; arnebacene; arnebidin; arnebin-7; phenolic compounds; geranylhydroquinone Arnebia hispidissima; arnebacene; arnebidin; arnebin-7; phenolic compounds; geranylhydroquinone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ahmed, A.F.; Saad, H.-E.A.; El-Karim, E.M.A. Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.. Molecules 2014, 19, 5940-5951.

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