Molecules 2014, 19(4), 5325-5347; doi:10.3390/molecules19045325
Article

Rice Bran Feruloylated Oligosaccharides Activate Dendritic Cells via Toll-Like Receptor 2 and 4 Signaling

1,2,3,4,* email, 5,* email, 6email, 5email, 7email, 8email, 2,3email, 3,9email and 10
Received: 29 January 2014; in revised form: 29 March 2014 / Accepted: 31 March 2014 / Published: 23 April 2014
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This work presents the effects of feruloylated oligosaccharides (FOs) of rice bran on murine bone marrow-derived dendritic cells (BMDCs) and the potential pathway through which the effects are mediated. We found that FOs induced phenotypic maturation of DCs, as shown by the increased expression of CD40, CD80/CD86 and MHC-I/II molecules. FOs efficiently induced maturation of DCs generated from C3H/HeN or C57BL/6 mice with normal toll-like receptor 4 (TLR-4) or TLR-2 but not DCs from mice with mutated TLR4 or TLR2. The mechanism of action of FOs may be mediated by increased phosphorylation of ERK, p38 and JNK mitogen-activated protein kinase (MAPKs) and increased NF-kB activity, which are important signaling molecules downstream of TLR-4 and TLR-2. These data suggest that FOs induce DCs maturation through TLR-4 and/or TLR-2 and that FOs might have potential efficacy against tumor or virus infection or represent a candidate-adjuvant approach for application in immunotherapy and vaccination.
Keywords: dendritic cells; feruloylated oligosaccharides; maturation; rice bran; Toll-like receptor (TLR)
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MDPI and ACS Style

Lin, C.C.; Chen, H.H.; Chen, Y.K.; Chang, H.C.; Lin, P.Y.; Pan, I.-H.; Chen, D.-Y.; Chen, C.M.; Lin, S.Y. Rice Bran Feruloylated Oligosaccharides Activate Dendritic Cells via Toll-Like Receptor 2 and 4 Signaling. Molecules 2014, 19, 5325-5347.

AMA Style

Lin CC, Chen HH, Chen YK, Chang HC, Lin PY, Pan I-H, Chen D-Y, Chen CM, Lin SY. Rice Bran Feruloylated Oligosaccharides Activate Dendritic Cells via Toll-Like Receptor 2 and 4 Signaling. Molecules. 2014; 19(4):5325-5347.

Chicago/Turabian Style

Lin, Chi C.; Chen, Hua H.; Chen, Yu K.; Chang, Hung C.; Lin, Ping Y.; Pan, I-Hong; Chen, Der-Yuan; Chen, Chuan M.; Lin, Su Y. 2014. "Rice Bran Feruloylated Oligosaccharides Activate Dendritic Cells via Toll-Like Receptor 2 and 4 Signaling." Molecules 19, no. 4: 5325-5347.


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