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Molecules 2014, 19(4), 5088-5108; doi:10.3390/molecules19045088

Natural Dibenzo-α-Pyrones and Their Bioactivities

MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
Author to whom correspondence should be addressed.
Received: 19 February 2014 / Revised: 16 April 2014 / Accepted: 16 April 2014 / Published: 22 April 2014
(This article belongs to the Section Natural Products)
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Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.
Keywords: dibenzo-α-pyrones; dibenzo-α-pyranones; 6H-benzo[c]chromen-6-ones; 6H-dibenzo[b,d]pyran-6-ones; biological activities dibenzo-α-pyrones; dibenzo-α-pyranones; 6H-benzo[c]chromen-6-ones; 6H-dibenzo[b,d]pyran-6-ones; biological activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mao, Z.; Sun, W.; Fu, L.; Luo, H.; Lai, D.; Zhou, L. Natural Dibenzo-α-Pyrones and Their Bioactivities. Molecules 2014, 19, 5088-5108.

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