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Molecules 2014, 19(4), 5088-5108; doi:10.3390/molecules19045088
Review

Natural Dibenzo-α-Pyrones and Their Bioactivities

, , , ,  and *
MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
* Author to whom correspondence should be addressed.
Received: 19 February 2014 / Revised: 16 April 2014 / Accepted: 16 April 2014 / Published: 22 April 2014
(This article belongs to the Section Natural Products)
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Abstract

Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.
Keywords: dibenzo-α-pyrones; dibenzo-α-pyranones; 6H-benzo[c]chromen-6-ones; 6H-dibenzo[b,d]pyran-6-ones; biological activities dibenzo-α-pyrones; dibenzo-α-pyranones; 6H-benzo[c]chromen-6-ones; 6H-dibenzo[b,d]pyran-6-ones; biological activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mao, Z.; Sun, W.; Fu, L.; Luo, H.; Lai, D.; Zhou, L. Natural Dibenzo-α-Pyrones and Their Bioactivities. Molecules 2014, 19, 5088-5108.

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