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Molecules 2014, 19(4), 4669-4680; doi:10.3390/molecules19044669

Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice

1, 1,†, 2,3,†, 1, 1 and 4,*
1 Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan 2 Graduate Institute of Athletics and Coaching Science, College of Sports and Athletics, National Taiwan Sport University, Taoyuan 33301, Taiwan 3 Center for Liberal Arts, Taipei Medical University, Taipei 11031, Taiwan 4 Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 February 2014 / Revised: 11 April 2014 / Accepted: 11 April 2014 / Published: 15 April 2014
(This article belongs to the Section Metabolites)
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Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.
Keywords: deer antler; grip strength; antifatigue deer antler; grip strength; antifatigue
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, C.-C.; Chen, Y.-M.; Kan, N.-W.; Chao, H.-L.; Ho, C.-S.; Hsu, M.-C. Cornu Cervi Pantotrichum Supplementation Improves Exercise Performance and Protects against Physical Fatigue in Mice. Molecules 2014, 19, 4669-4680.

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