Abstract: One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.
Keywords: (2R,3R)-7-O-galloylplumbocatechin A; Pithecellobium clypearia Benth; neuraminidase (NA) of influenza virus; anti-inflammatory activity
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Kang, J.; Liu, C.; Wang, H.; Li, B.; Li, C.; Chen, R.; Liu, A. Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth. Molecules 2014, 19, 4479-4490.
Kang J, Liu C, Wang H, Li B, Li C, Chen R, Liu A. Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth. Molecules. 2014; 19(4):4479-4490.
Kang, Jie; Liu, Chao; Wang, Hongqing; Li, Baoming; Li, Chao; Chen, Ruoyun; Liu, Ailin. 2014. "Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth." Molecules 19, no. 4: 4479-4490.