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Molecules 2014, 19(4), 4479-4490; doi:10.3390/molecules19044479

Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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Received: 28 January 2014 / Revised: 30 March 2014 / Accepted: 3 April 2014 / Published: 10 April 2014
(This article belongs to the Section Natural Products)
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Abstract

One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 14 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.
Keywords: (2R,3R)-7-O-galloylplumbocatechin A; Pithecellobium clypearia Benth; neuraminidase (NA) of influenza virus; anti-inflammatory activity (2R,3R)-7-O-galloylplumbocatechin A; Pithecellobium clypearia Benth; neuraminidase (NA) of influenza virus; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kang, J.; Liu, C.; Wang, H.; Li, B.; Li, C.; Chen, R.; Liu, A. Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth. Molecules 2014, 19, 4479-4490.

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