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Molecules 2014, 19(4), 4234-4245; doi:10.3390/molecules19044234
Article

Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera

1
, 2
, 1,2
 and 3,*
1 Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan 2 Tzu Hui Institute of Technology, Pingtung County 92641, Taiwan 3 Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
* Author to whom correspondence should be addressed.
Received: 12 February 2014 / Revised: 24 March 2014 / Accepted: 26 March 2014 / Published: 3 April 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Abstract

Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (−)-anonaine (1), (−)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
Keywords: Liriodendron tulipifera; scopoletin; antioxidative; (+)-norstephalagine Liriodendron tulipifera; scopoletin; antioxidative; (+)-norstephalagine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kang, Y.-F.; Liu, C.-M.; Kao, C.-L.; Chen, C.-Y. Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera. Molecules 2014, 19, 4234-4245.

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