Next Article in Journal
Development of Multi-Functional Chelators Based on Sarcophagine Cages
Next Article in Special Issue
Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation
Previous Article in Journal
Synthesis, Spectroscopic and Theoretical Studies of New Quaternary N,N-Dimethyl-3-phthalimidopropylammonium Conjugates of Sterols and Bile Acids
Previous Article in Special Issue
Ginsenoside Rb1 Protects Rat Neural Progenitor Cells against Oxidative Injury
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(4), 4234-4245; doi:10.3390/molecules19044234

Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera

Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
Tzu Hui Institute of Technology, Pingtung County 92641, Taiwan
Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan
Author to whom correspondence should be addressed.
Received: 12 February 2014 / Revised: 24 March 2014 / Accepted: 26 March 2014 / Published: 3 April 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
View Full-Text   |   Download PDF [312 KB, uploaded 18 June 2014]   |  


Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (−)-anonaine (1), (−)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
Keywords: Liriodendron tulipifera; scopoletin; antioxidative; (+)-norstephalagine Liriodendron tulipifera; scopoletin; antioxidative; (+)-norstephalagine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kang, Y.-F.; Liu, C.-M.; Kao, C.-L.; Chen, C.-Y. Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera. Molecules 2014, 19, 4234-4245.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top