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Molecules 2014, 19(3), 3617-3627; https://doi.org/10.3390/molecules19033617

Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

1
EA4267 Epithelial Functions and Dysfunctions, UFR of Medical and Pharmaceutical Sciences, 19 rue Ambroise Paré, 25030 Besançon, France
2
Rega Institute for Medical Research (KU Leuven), Minderbroedersstraat 10, B3000, Leuven, Belgium
3
Gif Research Center, Institute of Chemistry of Natural Substances (ICSN), CNRS, Labex CEBA, 1, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
*
Author to whom correspondence should be addressed.
Received: 21 February 2014 / Revised: 12 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC50 = 0.6 ± 0.1 µM, SI = 71.7). View Full-Text
Keywords: Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO) Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO)
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Bourjot, M.; Leyssen, P.; Neyts, J.; Dumontet, V.; Litaudon, M. Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication. Molecules 2014, 19, 3617-3627.

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