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Molecules 2014, 19(2), 2121-2134; doi:10.3390/molecules19022121
Article

Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore

1,2
, 3
, 3
, 4
, 1,4,*  and 1,2,*
Received: 20 January 2014; in revised form: 6 February 2014 / Accepted: 10 February 2014 / Published: 18 February 2014
(This article belongs to the collection Bioactive Compounds)
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Abstract: Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 15, together with five known saponins 610. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 68 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25–22.38 μM range.
Keywords: Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, X.; Wang, M.; Xu, M.; Wang, Y.; Tang, H.; Sun, X. Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore. Molecules 2014, 19, 2121-2134.

AMA Style

Wang X, Wang M, Xu M, Wang Y, Tang H, Sun X. Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore. Molecules. 2014; 19(2):2121-2134.

Chicago/Turabian Style

Wang, Xiaoyang; Wang, Minchang; Xu, Min; Wang, Yi; Tang, Haifeng; Sun, Xiaoli. 2014. "Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore." Molecules 19, no. 2: 2121-2134.


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