Next Article in Journal
Radiolabeling Strategies for Tumor-Targeting Proteinaceous Drugs
Next Article in Special Issue
Unravelling the Complex Antimicrobial Interactions of Essential Oils — The Case of Thymus vulgaris (Thyme)
Previous Article in Journal
The Suppressive Activities of Six Sources of Medicinal Ferns Known as Gusuibu on Heat-Labile Enterotoxin-Induced Diarrhea
Previous Article in Special Issue
Docking Studies in Target Proteins Involved in Antibacterial Action Mechanisms: Extending the Knowledge on Standard Antibiotics to Antimicrobial Mushroom Compounds
Molecules 2014, 19(2), 2121-2134; doi:10.3390/molecules19022121

Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore

1,4,*  and 1,2,*
Received: 20 January 2014 / Revised: 6 February 2014 / Accepted: 10 February 2014 / Published: 18 February 2014
(This article belongs to the collection Bioactive Compounds)
View Full-Text   |   Download PDF [492 KB, uploaded 18 June 2014]   |   Browse Figures


Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 15, together with five known saponins 610. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 68 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25–22.38 μM range.
Keywords: Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Wang, X.; Wang, M.; Xu, M.; Wang, Y.; Tang, H.; Sun, X. Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore. Molecules 2014, 19, 2121-2134.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert