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Molecules 2014, 19(2), 2121-2134; doi:10.3390/molecules19022121

Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore

1
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
2
Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China
3
Nuclear Magnetic Resonance Center, Xi'an Modern Chemistry Research Institute, Xi'an 710065, China
4
Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China
*
Authors to whom correspondence should be addressed.
Received: 20 January 2014 / Revised: 6 February 2014 / Accepted: 10 February 2014 / Published: 18 February 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 15, together with five known saponins 610. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 68 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25–22.38 μM range. View Full-Text
Keywords: Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity Anemone rivularis var. flore-minore; triterpenoid saponin; cytotoxicity
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MDPI and ACS Style

Wang, X.; Wang, M.; Xu, M.; Wang, Y.; Tang, H.; Sun, X. Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore. Molecules 2014, 19, 2121-2134.

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