Next Article in Journal
miRNA in Plasma Exosome is Stable under Different Storage Conditions
Previous Article in Journal
Gas Phase Thermal Reactions of exo-8-Cyclopropyl-bicyclo[4.2.0]oct-2-ene (1-exo)
Molecules 2014, 19(2), 1544-1567; doi:10.3390/molecules19021544
Review

Pharmacological Importance of Optically Active Tetrahydro-β-carbolines and Synthetic Approaches to Create the C1 Stereocenter

,
 and *
Laboratory of Organic Chemistry, Department of Chemistry, School of Chemical Tehcnology, Aalto University, PO Box 16100, Kemistintie 1, Aalto FI-00076, Finland
* Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 17 January 2014 / Accepted: 20 January 2014 / Published: 27 January 2014
(This article belongs to the Section Metabolites)

Abstract

1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.
Keywords: tetrahydro-β-carboline; THβC; pharmacological importance; biological activity; C1-substituted THβC tetrahydro-β-carboline; THβC; pharmacological importance; biological activity; C1-substituted THβC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Laine, A.E.; Lood, C.; Koskinen, A.M.P. Pharmacological Importance of Optically Active Tetrahydro-β-carbolines and Synthetic Approaches to Create the C1 Stereocenter. Molecules 2014, 19, 1544-1567.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert