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Molecules 2014, 19(2), 1411-1421; doi:10.3390/molecules19021411
Article

Ultrasound-Assisted Extraction of Mangiferin from Mango (Mangifera indica L.) Leaves Using Response Surface Methodology

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1 Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical College, Dongguan 523808, China 2 Department of Sanitary Inspection, School of Public Health, Guangdong Medical College, Dongguan 523808, China
* Author to whom correspondence should be addressed.
Received: 29 December 2013 / Revised: 20 January 2014 / Accepted: 20 January 2014 / Published: 27 January 2014
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Abstract

Mangiferin is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer, antidiabetic, immunomodulatory, hepatoprotective and analgesic effects. In the present study, an ultrasonic-assisted extraction method was developed for the effective extraction of mangiferin from mango leaves. Some parameters such as ethanol concentration, liquid-to-solid ratio, extraction temperature, and extraction time were optimized by single-factor experiment and response surface methodology. The optimal extraction conditions were 44% ethanol, the liquid-to-solid ratio was 38:1, and extraction for 19.2 min at 60 °C under ultrasound irradiation of 200 W. Under optimal conditions, the yield of mangiferin was 58.46 ± 1.27 mg/g. The results obtained are helpful for the full utilization of mango leaves, and also indicated that ultrasonic-assisted extraction is a very useful method for the extraction of mangiferin from plant materials.
Keywords: ultrasonic-assisted extraction; mangiferin; mango leaves; response surface methodology ultrasonic-assisted extraction; mangiferin; mango leaves; response surface methodology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zou, T.-B.; Xia, E.-Q.; He, T.-P.; Huang, M.-Y.; Jia, Q.; Li, H.-W. Ultrasound-Assisted Extraction of Mangiferin from Mango (Mangifera indica L.) Leaves Using Response Surface Methodology. Molecules 2014, 19, 1411-1421.

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