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Molecules 2014, 19(11), 19243-19252; doi:10.3390/molecules191119243

Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

1
NuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, UNESP, Universidade Estadual Paulista, Araraquara-SP 14800-900, Brazil
2
Instituto de Ciências Exatas, Universidade Federal de Viçosa, Viçosa, MG, 38810-000, Brazil
3
Instituto de Botânica, Núcleo de Pesquisa em Fisiologia e Bioquímica, São Paulo-SP, 04301-902, Brazil
4
Departamento de Fitopatologia, Universidade Federal de Lavras, Lavras, MG, 37200-000, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 October 2014 / Revised: 14 November 2014 / Accepted: 14 November 2014 / Published: 21 November 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [353 KB, uploaded 21 November 2014]   |  

Abstract

In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl)acetic acid (6), 4-hydroxy- benzamide (7) and 2(2-hydroxyphenyl)acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 18 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin. View Full-Text
Keywords: Colletotrichum gloeosporioides; endophytic fungus; antifungal activity Colletotrichum gloeosporioides; endophytic fungus; antifungal activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chapla, V.M.; Zeraik, M.L.; Leptokarydis, I.H.; Silva, G.H.; Bolzani, V.S.; Young, M.C.M.; Pfenning, L.H.; Araújo, A.R. Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules 2014, 19, 19243-19252.

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