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Molecules 2014, 19(11), 18897-18910; doi:10.3390/molecules191118897

Synthesis, Characterization and Antimicrobial Evaluation of Some New Schiff, Mannich and Acetylenic Mannich Bases Incorporating a 1,2,4-Triazole Nucleus

1
Department of Chemistry, Faculty of Sciences, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia
2
Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf, B.p. 1505 El M'nouar, Oran 31000, Algeria 
Received: 31 August 2014 / Revised: 29 October 2014 / Accepted: 3 November 2014 / Published: 18 November 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of Schiff and Mannich bases derived from 4-amino-5-(3-fluoro-phenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione were synthesized. The alkylation of 4-phenyl-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione with propargyl bromide afforded the corresponding thiopropargylated derivative which upon treatment with the appropriate secondary amines in the presence of CuCl2 furnished the desired acetylenic Mannich bases. The synthesized compounds were characterized on the basis of their spectral (IR, 1H- and 13C-NMR) data and evaluated for their biological activities. Some of the compounds were found to exhibit significant antimicrobial activity. View Full-Text
Keywords: Schiff bases; Mannich bases; acetylenic Mannich bases; 1,2,4-triazole; antimicrobial activity Schiff bases; Mannich bases; acetylenic Mannich bases; 1,2,4-triazole; antimicrobial activity
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MDPI and ACS Style

Aouad, M.R. Synthesis, Characterization and Antimicrobial Evaluation of Some New Schiff, Mannich and Acetylenic Mannich Bases Incorporating a 1,2,4-Triazole Nucleus. Molecules 2014, 19, 18897-18910.

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