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Molecules 2014, 19(11), 17735-17746; doi:10.3390/molecules191117735

Hepatoprotective Effect of the Aqueous Extract of Simarouba amara Aublet (Simaroubaceae) Stem Bark against Carbon Tetrachloride (CCl4)-Induced Hepatic Damage in Rats

1
Department of Pharmaceutical Sciences, Universidade Federal de Pernambuco, Recife 50740-521, Brazil
2
Department of Histology and Embriology, Universidade Federal de Pernambuco, Recife 50670-901, Brazil
3
Department of Physical Education and Sport Science, Universidade Federal de Pernambuco, Vitória de Santo Antão 55608-680, Brazil
4
Department of Nutrition, Universidade Federal de Pernambuco, Vitória de Santo Antão 55608-680, Brazil
5
Department of Physiology and Pharmacology, Universidade Federal de Pernambuco, Recife 50760-901, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 September 2014 / Revised: 10 October 2014 / Accepted: 21 October 2014 / Published: 31 October 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Abstract

Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of the aqueous extract of S. amara stem bark (SAAE) on CCl4-induced hepatic damage in rats. SAAE was evaluated by high performance liquid chromatography. The animals were divided into six groups (n = 6/group). Groups I (vehicle—corn oil), II (control-CCl4), III, IV, V and VI were pretreated during 10 consecutive days, once a day p.o, with Legalon® 50 mg/kg b.w, SAAE at doses 100, 250 and 500 mg/kg b.w, respectively. The hepatotoxicity was induced on 11th day with 2 mL/kg of 20% CCl4 solution. 24 h after injury, the blood samples were collected and their livers were removed to biochemical and immunohistochemical analyzes. The SAAE decreased the levels of liver markers and lipid peroxidation in all doses and increased the catalase levels at doses 250 and 500 mg/kg. Immunohistochemical results suggested hepatocyte proliferation in all doses. These results may be related to catechins present in SAAE. Thus, SAAE prevented the oxidative damage at the same time that increased regenerative and reparative capacities of the liver. View Full-Text
Keywords: Simaroubaceae; Simarouba amara; carbon tetrachloride; catechin; hepatoprotection; antioxidant Simaroubaceae; Simarouba amara; carbon tetrachloride; catechin; hepatoprotection; antioxidant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Maranhão, H.M.L.; Vasconcelos, C.F.B.; Rolim, L.A.; Neto, P.J.R.; Neto, J.C.S.; Filho, R.C.S.; Fernandes, M.P.; Costa-Silva, J.H.; Araújo, A.V.; Wanderley, A.G. Hepatoprotective Effect of the Aqueous Extract of Simarouba amara Aublet (Simaroubaceae) Stem Bark against Carbon Tetrachloride (CCl4)-Induced Hepatic Damage in Rats. Molecules 2014, 19, 17735-17746.

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