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Molecules 2014, 19(11), 17435-17463; doi:10.3390/molecules191117435

Advances in Metal-Catalyzed Cross-Coupling Reactions of Halogenated Quinazolinones and Their Quinazoline Derivatives

Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa
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Received: 26 August 2014 / Revised: 10 October 2014 / Accepted: 21 October 2014 / Published: 29 October 2014
(This article belongs to the Section Organic Synthesis)

Abstract

Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview of the application of these methods on halogenated quinazolin-4-ones and their quinazolines to generate novel polysubstituted derivatives. View Full-Text
Keywords: halogenoquinazolin-4-ones; halogenoquinazolines; cross-coupling reactions halogenoquinazolin-4-ones; halogenoquinazolines; cross-coupling reactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mphahlele, M.J.; Maluleka, M.M. Advances in Metal-Catalyzed Cross-Coupling Reactions of Halogenated Quinazolinones and Their Quinazoline Derivatives. Molecules 2014, 19, 17435-17463.

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