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Molecules 2014, 19(10), 16529-16542; doi:10.3390/molecules191016529

The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China

1
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
2
Tibet Plateau Institute of Biology, Lhasa 850001, China
3
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Received: 7 August 2014 / Revised: 17 September 2014 / Accepted: 19 September 2014 / Published: 14 October 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Four new anthraquinone derivatives 14 were obtained along with seven known compounds 511 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively. View Full-Text
Keywords: Alternaria; secondary metabolites; anthraquinones; alterporriols; altersolanols; cytotoxicity; enzyme inhibitory activity Alternaria; secondary metabolites; anthraquinones; alterporriols; altersolanols; cytotoxicity; enzyme inhibitory activity
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Chen, B.; Shen, Q.; Zhu, X.; Lin, Y. The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China. Molecules 2014, 19, 16529-16542.

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