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Molecules 2014, 19(10), 15866-15890; doi:10.3390/molecules191015866

New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, D-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity

1
National Institute of Public Health—National Institute of Hygiene, Chocimska 24, Warsaw 00-791, Poland
2
Institute of Chemistry, Siedlce University, 3.Maja 54, Siedlce 80-110, Poland
*
Authors to whom correspondence should be addressed.
Received: 14 August 2014 / Revised: 17 September 2014 / Accepted: 22 September 2014 / Published: 30 September 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS·+), superoxide anion radical (O2·−) and nitric oxide radical (·NO) assays. We also studied D-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases. View Full-Text
Keywords: free radicals; scavenger; DAAO; AChE; BuChE; inhibitor; 3,4-dihydroisoquinoline free radicals; scavenger; DAAO; AChE; BuChE; inhibitor; 3,4-dihydroisoquinoline
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Solecka, J.; Guśpiel, A.; Postek, M.; Ziemska, J.; Kawęcki, R.; Łęczycka, K.; Osior, A.; Pietrzak, B.; Pypowski, K.; Wyrzykowska, A. New Derivatives of 3,4-Dihydroisoquinoline-3-carboxylic Acid with Free-Radical Scavenging, D-Amino Acid Oxidase, Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity. Molecules 2014, 19, 15866-15890.

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