Molecules 2014, 19(1), 911-924; doi:10.3390/molecules19010911
Article

A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity

1 and 1,2,* email
Received: 2 December 2013; in revised form: 30 December 2013 / Accepted: 30 December 2013 / Published: 14 January 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper presents the design of some novel 3-acetylcoumarin derivatives, based on minimal inhibitory concentration values (MICs) previously obtained against some microorganism cultures, Gram positive and negative bacteria and fungi. Some of these molecules exhibited antibacterial activity against S. aureus, comparable to that of the standard used (impinem). The in vitro antioxidant activities of the novel 3-acetylcoumarin oxadiazoles were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method. The compounds 5c,d proved to be the most active, showing the highest capacity to deplete the DPPH radicals. Structure elucidation of the products has been accomplished on the basis of IR, 1H-NMR, 13C-NMR, NOESY and HMBC NMR data.
Keywords: radical scavenging activity; antibacterial; antifungal, antioxydant, coumarin
PDF Full-text Download PDF Full-Text [308 KB, uploaded 18 June 2014 20:22 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Ayed, A.S.; Hamdi, N. A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity. Molecules 2014, 19, 911-924.

AMA Style

Al-Ayed AS, Hamdi N. A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity. Molecules. 2014; 19(1):911-924.

Chicago/Turabian Style

Al-Ayed, Abdullah S.; Hamdi, Naceur. 2014. "A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity." Molecules 19, no. 1: 911-924.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert