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Molecules 2014, 19(1), 911-924; doi:10.3390/molecules19010911
Article

A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity

1 and 1,2,*
1 Chemistry Department, College of Science and Arts, Al-Rass, P.O. Box 53, Qassim University, Buraidah 51477, Saudi Arabia 2 Higher Institute of Environmental Science and Technologies (HIEST-Borj Cedria, Tunisia), University of Carthage, Touristic Road of Soliman, BP 95, Hammam-Lif 2050, Tunisia
* Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 30 December 2013 / Accepted: 30 December 2013 / Published: 14 January 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

This paper presents the design of some novel 3-acetylcoumarin derivatives, based on minimal inhibitory concentration values (MICs) previously obtained against some microorganism cultures, Gram positive and negative bacteria and fungi. Some of these molecules exhibited antibacterial activity against S. aureus, comparable to that of the standard used (impinem). The in vitro antioxidant activities of the novel 3-acetylcoumarin oxadiazoles were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method. The compounds 5c,d proved to be the most active, showing the highest capacity to deplete the DPPH radicals. Structure elucidation of the products has been accomplished on the basis of IR, 1H-NMR, 13C-NMR, NOESY and HMBC NMR data.
Keywords: radical scavenging activity; antibacterial; antifungal, antioxydant, coumarin radical scavenging activity; antibacterial; antifungal, antioxydant, coumarin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Ayed, A.S.; Hamdi, N. A New and Efficient Method for the Synthesis of Novel 3-Acetyl Coumarins Oxadiazoles Derivatives with Expected Biological Activity. Molecules 2014, 19, 911-924.

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