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Molecules 2014, 19(1), 826-845; doi:10.3390/molecules19010826
Article

Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids

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Received: 9 December 2013; in revised form: 20 December 2013 / Accepted: 25 December 2013 / Published: 10 January 2014
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Abstract: The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives.
Keywords: multi-component reaction; nickel(II); glycine; diastereoselectivity; unnatural amino acids multi-component reaction; nickel(II); glycine; diastereoselectivity; unnatural amino acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhou, R.; Guo, L.; Peng, C.; He, G.; Ouyang, L.; Huang, W. Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids. Molecules 2014, 19, 826-845.

AMA Style

Zhou R, Guo L, Peng C, He G, Ouyang L, Huang W. Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids. Molecules. 2014; 19(1):826-845.

Chicago/Turabian Style

Zhou, Rui; Guo, Li; Peng, Cheng; He, Gu; Ouyang, Liang; Huang, Wei. 2014. "Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids." Molecules 19, no. 1: 826-845.



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