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Molecules 2014, 19(1), 826-845; doi:10.3390/molecules19010826
Article

Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids

1
,
1
,
2
,
1,* , 1
 and
1,2,*
1 State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China 2 State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan, China
* Authors to whom correspondence should be addressed.
Received: 9 December 2013 / Revised: 20 December 2013 / Accepted: 25 December 2013 / Published: 10 January 2014
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Abstract

The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives.
Keywords: multi-component reaction; nickel(II); glycine; diastereoselectivity; unnatural amino acids multi-component reaction; nickel(II); glycine; diastereoselectivity; unnatural amino acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhou, R.; Guo, L.; Peng, C.; He, G.; Ouyang, L.; Huang, W. Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids. Molecules 2014, 19, 826-845.

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