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Molecules 2014, 19(1), 819-825; doi:10.3390/molecules19010819
Article

Pestalafuranones F–J, Five New Furanone Analogues from the Endophytic Fungus Nigrospora sp. BM-2

, * , , ,  and *
Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China
* Authors to whom correspondence should be addressed.
Received: 9 December 2013 / Revised: 3 January 2014 / Accepted: 3 January 2014 / Published: 10 January 2014
(This article belongs to the Section Metabolites)
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Abstract

Five new 2(5H)-furanone-type derivatives, pestalafuranones F–J (compounds 37), together with two known compounds, pestalafuranones A (1) and B (2), were isolated from the ethyl acetate extract from the fermentation broth of the endophytic fungus Nigrospora sp. BM-2 in a hypersaline medium. The structures of these metabolites were elucidated by EIMS, HREIMS and NMR spectroscopic data. Compounds 17 exhibited no cytotoxic activities against the MDA-MB-231 and Caski cancer cell lines.
Keywords: pestalafuranones F–J; endophytic fungus; Nigrospora sp.; cytotoxic activity pestalafuranones F–J; endophytic fungus; Nigrospora sp.; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.; Deng, Z.; Guo, Z.; Tu, X.; Wang, J.; Zou, K. Pestalafuranones F–J, Five New Furanone Analogues from the Endophytic Fungus Nigrospora sp. BM-2. Molecules 2014, 19, 819-825.

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