Abstract: The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.
Keywords: 2-aryl-6,8-dibromoquinazolin-4(3H)-ones; 2-aryl-6,8-dibromo-4-chloroquinazolines; Sonogashira cross-coupling; 2-aryl-6,8-dibromo-4-(alkynyl)quinazolines; Suzuki cross-coupling; 2,6,8-triaryl-4-(phenylethynyl)quinazolines; photophysical properties
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Mphahlele, M.J.; Paumo, H.K.; El-Nahas, A.M.; El-Hendawy, M.M. Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines. Molecules 2014, 19, 795-818.
Mphahlele MJ, Paumo HK, El-Nahas AM, El-Hendawy MM. Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines. Molecules. 2014; 19(1):795-818.
Mphahlele, Malose J.; Paumo, Hugues K.; El-Nahas, Ahmed M.; El-Hendawy, Morad M. 2014. "Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines." Molecules 19, no. 1: 795-818.