Molecules 2014, 19(1), 795-818; doi:10.3390/molecules19010795

Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

1,* , 1
, 2
 and 3,4
Received: 29 October 2013; in revised form: 30 December 2013 / Accepted: 6 January 2014 / Published: 10 January 2014
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [1432 KB, uploaded 18 June 2014]
Abstract: The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.
Keywords: 2-aryl-6,8-dibromoquinazolin-4(3H)-ones; 2-aryl-6,8-dibromo-4-chloroquinazolines; Sonogashira cross-coupling; 2-aryl-6,8-dibromo-4-(alkynyl)quinazolines; Suzuki cross-coupling; 2,6,8-triaryl-4-(phenylethynyl)quinazolines; photophysical properties
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Mphahlele, M.J.; Paumo, H.K.; El-Nahas, A.M.; El-Hendawy, M.M. Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines. Molecules 2014, 19, 795-818.

AMA Style

Mphahlele MJ, Paumo HK, El-Nahas AM, El-Hendawy MM. Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines. Molecules. 2014; 19(1):795-818.

Chicago/Turabian Style

Mphahlele, Malose J.; Paumo, Hugues K.; El-Nahas, Ahmed M.; El-Hendawy, Morad M. 2014. "Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines." Molecules 19, no. 1: 795-818.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert