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Molecules 2013, 18(9), 11086-11099; doi:10.3390/molecules180911086

First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

1, 1, 2, 1, 1, 1, 1, 3, 3, 4, 5 and 1,*
Received: 21 June 2013 / Revised: 29 August 2013 / Accepted: 29 August 2013 / Published: 10 September 2013
(This article belongs to the Section Metabolites)
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The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 132-hydroxyphaeophytin A (6), 173-ethoxypheophorbide A (7), 132-hydroxy-173-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by 1H and 13C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time.
Keywords: phytochemical study; Cordia exaltata Lam.; Boraginaceae; antimicrobial activity phytochemical study; Cordia exaltata Lam.; Boraginaceae; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bezerra de Sá de Sousa Nogueira, T.; Bezerra de Sá de Sousa Nogueira, R.; Antas e Silva, D.; Tavares, J.F.; de Oliveira Lima, E.; de Oliveira Pereira, F.; de Souza Fernandes, M.M.M.; de Medeiros, F.A.; do Socorro Ferreira Rodrigues Sarquis, R.S.F.R.; Filho, R.B.; da Silva Maciel, J.K.; de Fátima Vanderlei de Souza, M. First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans. Molecules 2013, 18, 11086-11099.

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