Molecules 2013, 18(9), 11086-11099; doi:10.3390/molecules180911086
Article

First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

1 Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil 2 Department of Physiology and Pathology, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil 3 Institute for Scientific and Technological Research of Amapá, Macapá, AP 68901-025, Brazil 4 Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro-UFRRJ, Campos dos Goytacazes, RJ 28013-602, Brazil 5 Postgraduate Program in Development and Technological Innovation in Drug-Center for Health Sciences, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil
* Author to whom correspondence should be addressed.
Received: 21 June 2013; in revised form: 29 August 2013 / Accepted: 29 August 2013 / Published: 10 September 2013
(This article belongs to the Section Metabolites)
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Abstract: The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 132-hydroxyphaeophytin A (6), 173-ethoxypheophorbide A (7), 132-hydroxy-173-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by 1H and 13C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time.
Keywords: phytochemical study; Cordia exaltata Lam.; Boraginaceae; antimicrobial activity

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MDPI and ACS Style

Bezerra de Sá de Sousa Nogueira, T.; Bezerra de Sá de Sousa Nogueira, R.; Antas e Silva, D.; Tavares, J.F.; de Oliveira Lima, E.; de Oliveira Pereira, F.; de Souza Fernandes, M.M.M.; de Medeiros, F.A.; do Socorro Ferreira Rodrigues Sarquis, R.S.F.R.; Filho, R.B.; da Silva Maciel, J.K.; de Fátima Vanderlei de Souza, M. First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans. Molecules 2013, 18, 11086-11099.

AMA Style

Bezerra de Sá de Sousa Nogueira T, Bezerra de Sá de Sousa Nogueira R, Antas e Silva D, Tavares JF, de Oliveira Lima E, de Oliveira Pereira F, de Souza Fernandes MMM, de Medeiros FA, do Socorro Ferreira Rodrigues Sarquis RSFR, Filho RB, da Silva Maciel JK, de Fátima Vanderlei de Souza M. First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans. Molecules. 2013; 18(9):11086-11099.

Chicago/Turabian Style

Bezerra de Sá de Sousa Nogueira, Tiago; Bezerra de Sá de Sousa Nogueira, Raquel; Antas e Silva, Davi; Tavares, Josean F.; de Oliveira Lima, Edeltrudes; de Oliveira Pereira, Fillipe; de Souza Fernandes, Milen M.M.; de Medeiros, Fernando A.; do Socorro Ferreira Rodrigues Sarquis, Rosangela S.F.R.; Filho, Raimundo B.; da Silva Maciel, Jéssica K.; de Fátima Vanderlei de Souza, Maria. 2013. "First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans." Molecules 18, no. 9: 11086-11099.

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